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Clinical Trans Gastroenterology : 急诊科医师使用氟哌啶醇治疗胃肠道症状的效果分析

2021-06-08 MedSci原创 MedSci原创

在美国,腹痛是患者急诊就诊的最主要原因,其次是恶心/呕吐。在急诊科,临床医生已经使用了多种疗法来治疗患者的恶心和呕吐,尤其是胃轻瘫引起的恶心和呕吐等症状。

      在美国,腹痛是患者急诊就诊的最主要原因,其次是恶心/呕吐。在急诊科,临床医生已经使用了多种疗法来治疗患者的恶心和呕吐,尤其是胃轻瘫引起的恶心和呕吐等症状,包括胃复安、昂丹司琼、劳拉西泮,以及最近的氟哌啶醇(HL)药物。

 

      HL是一种多巴胺拮抗剂。它属于第一代抗精神病药,原本用于治疗精神分裂症和相关疾病,HL还可作用于胃和脑的化学感受器触发区,减少恶心和呕吐的发生。HL 还被证明对周期性呕吐综合征 (CVS) 和大麻素剧吐综合征 (CHS) 具有治疗效果。急诊室中使用 HL还可以减少吗啡镇痛药的使用,并减少胃轻瘫急性加重患者的住院率。因此,本项研究旨在对就诊于急诊科的出现胃肠 (GI) 症状(恶心、呕吐和腹痛)而接受 HL 的患者临床改善的结果和预测因素进行探究。

 

      研究人员回顾性分析了在 2016 年 8 月至 2019 年 3 月期间就诊于急诊室的患者记录,所有患者均有胃肠道症状并接受了 HL治疗。研究结果显示总共有 281 名患者出现胃肠道症状并接受 HL 治疗:66% 为女性,32% 患有糖尿病,68% 使用过大麻,27% 使用慢性阿片类药物。所有患者均接受 HL 1.1 ± 0.3 次治疗,剂量为 2.5 ± 3.0 mg,主要使用方式是静脉注射(84.6%)。总住院时间为 7.5 ± 3.9 小时(HL 前 3.2 ± 2.1 小时,HL 后 4.4 ± 3.4 小时)。大约 4.4% 的患者出现了 HL 的副作用,其中 2 名患者出现肌张力障碍,但患者在出院前通过药物治疗得到改善。大多数患者 (56.6%) 出院回家,而 43.2% 住院主要是因为顽固性恶心或呕吐 (70.1%)。糖尿病、大麻素使用、焦虑、男性和延长 ED 住院时间与住院人数增加有关,与HL的使用无关。

图:对于延长住院时间的危险因素展示

 

      本项研究证实大多数在急诊科因胃肠道症状(尤其是恶心、呕吐和/或腹痛)就诊而接受 HL 治疗的患者均成功治疗并出院回家。HL 的使用相对安全,还可以降低再住院几率。

 

 

原始出处:

Shahsavari, Dariush. Et al. Haloperidol Use in the Emergency Department for Gastrointestinal Symptoms: Nausea, Vomiting, and Abdominal Pain. Clinical and Translational Gastroenterology.2021.

 

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    2021-07-11 bsmagic9140
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13:06:27 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508446, encodeId=a6e1150844603, content=<a href='/topic/show?id=a4c96391448' target=_blank style='color:#2F92EE;'>#氟哌啶醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63914, encryptionId=a4c96391448, topicName=氟哌啶醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14ae9959934, createdName=venlin, createdTime=Thu Jun 10 13:06:27 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
  5. 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13:06:27 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508446, encodeId=a6e1150844603, content=<a href='/topic/show?id=a4c96391448' target=_blank style='color:#2F92EE;'>#氟哌啶醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63914, encryptionId=a4c96391448, topicName=氟哌啶醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14ae9959934, createdName=venlin, createdTime=Thu Jun 10 13:06:27 CST 2021, time=2021-06-10, status=1, ipAttribution=)]
    2021-11-09 许安
  6. 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  7. 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    2021-06-10 zll0628
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NEJM:氟哌啶醇和齐拉西酮治疗重症疾病患者谵妄的疗效

由此可见,与安慰剂相比,在ICU中急性呼吸衰竭或休克以及低活性或过度活跃的谵妄患者中使用氟哌啶醇或齐拉西酮并未显著改善谵妄的持续时间。

BMJ:氟哌啶醇治疗与急性心肌梗死死亡风险

研究发现,氟哌啶醇治疗导致的急性心肌梗死死亡风险略高于其他非典型抗精神病药物,虽然不能排除混淆因素,但心血管风险高危患者在使用氟哌啶醇时因充分考虑这一潜在风险

Anesthesiology:预防性使用氟哌啶醇对谵妄高风险的III级危重患者长期生活质量的影响

重症监护病房患者谵妄发生率高,且与长期预后受损有关。预防性使用氟哌啶醇并没有改善谵妄高风险的危重患者的短期预后。本研究评估预防性使用氟哌啶醇对这些患者长期生活质量的影响,并探讨哪些因素与生活质量的改变有关。

ICU中的谵妄和氟哌啶醇:以手指月

氟哌啶醇,合成于60年前的1958年2月,是一种卓越的神经安定剂。诞生以来用于数十万计精神分裂症及其他精神病患者,尤其用于治疗精神病引起的躁动,并被纳入世界卫生组织的基本药物清单。

NEJM:氟哌啶醇和齐拉西酮治疗重症患者谵妄症毫无建树

2018年10月,美国学者在《N Engl J Med》发表的一项研究,考察了氟哌啶醇和齐拉西酮治疗重症患者谵妄症的有效性和安全性。

NEJM:氟哌啶醇不能降低 ICU 患者谵妄持续时间

谵妄是危重病期间急性脑功能障碍的最常见表现,ICU 机械通气患者的发生率为50-75%。谵妄患者的死亡率更高,机械通气和住院时间更长,花费更高,并且往往面临高风险的长期认知功能障碍。谵妄也会妨碍医疗和护理。多动性谵妄(Hyperactive delirium)会意外拔出各种设备,而低活动性谵妄(hypoactive delirium)会不配合护理、物理治疗和职业治疗。

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