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Diabetes Care:2型糖尿病患者抗阻力训练中骨骼肌微血管参与改善血糖控制!

2017-07-08 xing.T MedSci原创

由此可见,RT可以改善OGC刺激的肌肉MBF和血糖控制,这表明MBF在RT改善的血糖控制发挥了作用。

胰岛素能够增加葡萄糖的处理部分是通过促进微血管血流量(MBF)和底物输送到细胞来实现。胰岛素抵抗和2型糖尿会导致胰岛素微血管功能受损。抗阻训练(RT)可改善血糖控制和胰岛素敏感性,但这种改善是否与2型糖尿病患者增强骨骼肌微血管反应有关尚不清楚。

近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,研究人员纳入了十七例(11名男性6名女性;52±2岁)久坐不动的2型糖尿病患者,这些参与者进行6周的全身RT训练,在RT前后,参与者禁食过夜,对临床化学指标进行测量(血脂、血糖、糖化血红蛋白、胰岛素、糖基化终末产物)和接受口服葡萄糖实验(OGC)(50g×2h)。研究人员采用超声造影评估了前臂肌肉MBF,通过激光多普勒评估皮肤MBF,通过多普勒超声在基线和OGC60分钟后评估肱动脉血流。在RT评估身体成分前后进行全身DEXA扫描。

在RT后,对OGC反应的肌肉MBF增加,而皮肤微血管的反应是不变的。这些微血管改变伴随着血糖控制的改善(空腹血糖、糖化血红蛋白和OGC期间葡萄糖曲线下面积[AUC])并且增加精瘦体重,减少空腹血浆甘油三酯、总胆固醇、糖基化终末产物和全身脂肪。在RT后肌肉MBF响应的变化与空腹血糖、糖化血红蛋白以及OGC AUC的降低明显相关,在调整了年龄、性别、身体脂肪百分比和精瘦体重百分比。

由此可见,RT可以改善OGC刺激的肌肉MBF和血糖控制,这表明MBF在RT改善的血糖控制发挥了作用。

原始出处:

Ryan D. Russell,et al. Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes.Diabetes Care 2017. https://doi.org/10.2337/dc16-2750

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    2017-07-18 lou.minghong

    所以不能仅强调有氧运动!

    0

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  8. 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  9. 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    2017-07-10 mgqwxj
  10. 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