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J Int Adv Otol:突发感官听力损失患者血清中循环免疫复合物和热激蛋白70研究

2018-12-23 AlexYang MedSci原创

最近,有研究人员分析了评估了热激蛋白70(Hsp70)和循环免疫复合物(CIC)在患有突发感官听力损失(SSHL)患者中的作用,地点在一个研究性大学的高级护理中心(2014-2017)。研究人员对参与者的疾病历史进行了访谈,并对耳朵、鼻子和咽喉(ENT)进行了检查,还进行了听力测试。之后对CIC和Hsp70蛋白进行了分析。研究人员还进行了简单的斑点杂交方法来鉴定结合到CIC上的Hsp70游离Hsp

最近,有研究人员分析了评估了热激蛋白70(Hsp70)和循环免疫复合物(CIC)在患有突发感官听力损失(SSHL)患者中的作用,地点在一个研究性大学的高级护理中心(2014-2017)。

研究人员对参与者的疾病历史进行了访谈,并对耳朵、鼻子和咽喉(ENT)进行了检查,还进行了听力测试。之后对CIC和Hsp70蛋白进行了分析。研究人员还进行了简单的斑点杂交方法来鉴定结合到CIC上的Hsp70游离Hsp70。研究发现,在患有先天性SSHL的59.4%患者中,免疫复合物的水平提高。与健康参与者相比,研究人员观察到了显著的差异。在48.4%的患者中,研究人员观察到了阳性游离Hsp70蛋白反应。在对照组,游离Hsp70蛋白在8%的参与者中观察到(p=0.0000034)。另外,研究人员在62.5%的患者中检测到了Hsp70结合到CIC情况,健康参与者中为12%(p<0.0001)。

最后,研究人员指出,在SSHL患者的血清中,CIC和Hsp70蛋白的水平提高。另外,结合到CIC上的Hsp70蛋白鼻游离Hsp70蛋白水平显著更高,并且也能通过蛋白免疫印迹检测到。斑点杂交方法增加了Hsp70的鉴定可靠性,同时也提高了SSHL自身免疫检测的可能性。

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    2018-12-25 ysjykql
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Occup Environ Med:中国火车驾驶员的职业环境和听力损失研究

世界范围内,由高水平的噪音引起的听力损失是火车驾驶员的一种潜在的职业健康障碍。最近,有研究人员调查了隧道驾驶职业环境与火车驾驶员听力损失之间的相关性,从而为减少火车驾驶员的听力损失提供新的认知。研究包括了1214名中国广州铁路的火车驾驶员,并分析了其代表性的数据。另外,具有职业执照的医生对其进行健康检查,并在一个声音隔离的房间,健康专家对听力进行了测试,并利用了多变量模型和分层模型以及多变量逻辑回

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