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JACC:更低的社会经济状态能独立预测不良心血管疾病风险

2019-06-28 不详 MedSci原创

低的社会经济状态(SES)与更高的不良心血管疾病风险(MACE)相关,但其具体机制尚不清楚。由于低SES人的社会心理压力会更大,所以本研究的目的旨在探究压力相关的神经生物学改变参与了低SES与MACE的相关性。 本研究纳入了509名研究对象(平均年龄55岁),对其进行了全身18F氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描成像。经过超过4年时间的随访,有40个人发生了MACE,基线的个

低的社会经济状态(SES)与更高的不良心血管疾病风险(MACE)相关,但其具体机制尚不清楚。由于低SES人的社会心理压力会更大,所以本研究的目的旨在探究压力相关的神经生物学改变参与了低SESMACE的相关性。

 

本研究纳入了509名研究对象(平均年龄55岁),对其进行了全身18F氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描成像。经过超过4年时间的随访,有40个人发生了MACE,基线的个人收入与杏仁核活性( β: 0.157 [95% (CI): 0.266 - 0.041]; p = 0.007)和动脉炎症(β: 0.10 [95% CI: 0.18 - 0.14]; p = 0.022)呈负相关性。经多变量调整后,发现收入与后续的MACE发生也呈相关性(HR:0.67 [95% CI: 0.47-0.96]; p = 0.029)。

 

研究结果显示,更低的社会经济状态与杏仁核活性升高相关,且能独立预测主要不良心血管疾病风险。


原始出处:

Ahmed T et al.Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease.JACC.2019 June.


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    2019-09-19 hbwxf
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    2019-06-28 龙胆草

    学习谢谢分享

    0

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JACC:血清电解质浓度与心电图改变呈相关性

心电图的亚临床改变是心血管死亡的风险因素,目前对心脏电生理学中电解质相关性的认识仅基于严重疾病患者的体外模型和观察。本研究的目的旨在评估血清电解质浓度与心电图改变的相关性。本次荟萃分析纳入了来自33个临床研究中的153014名研究对象(女性占54.4%,平均年龄55.1±12.1岁 ),并对研究对象的电解质浓度(钙、钾、钠、镁)和心电图的间期(RR、QT、QRS、JT和PR)相关性进行了线性回归分

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