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Heart| 巧克力降低房颤风险?

2017-06-27 BMJ BMJ

研究人员发现,定期摄入巧克力可能与不规则心房颤动的风险低有关,该研究在线发表于BMJ旗下的Heart期刊中。研究建议,女性1周摄入1次巧克力,男性1周摄入2到6次,这样的频率与房颤低风险的相关性最强。在全世界,房颤影响着超过3300万人,每4个成年人中就有1个可能会遭遇房颤。造成房颤的原因仍不清楚,但当前不能治愈也无法预防。考虑到定期的巧克力摄入,尤其是黑巧克力,可能会改善心脏健康的各项指标,研究



研究人员发现,定期摄入巧克力可能与不规则心房颤动的风险低有关,该研究在线发表于BMJ旗下的Heart期刊中。研究建议,女性1周摄入1次巧克力,男性1周摄入2到6次,这样的频率与房颤低风险的相关性最强。

在全世界,房颤影响着超过3300万人,每4个成年人中就有1个可能会遭遇房颤。造成房颤的原因仍不清楚,但当前不能治愈也无法预防。考虑到定期的巧克力摄入,尤其是黑巧克力,可能会改善心脏健康的各项指标,研究人员希望探索巧克力摄入是否也与房颤低风险相关。

研究者从丹麦“饮食、癌症与健康”研究里招募了55,502位参与人员,年龄为50-64岁。参与者提供他们每周通常的巧克力摄入量,摄入1次被定为30g。他们没有被要求说明巧克力类型。但丹麦的巧克力大多数是牛奶巧克力(可可粉含量≥30%)。

研究招募参与者时记录了他们的心脏病风险因素、饮食和生活方式等信息——约1/3为吸烟者。参与者健康状况由国家注册数据记录的病情发作、住院治疗和死亡情况提供。

巧克力摄入量更高的人日常卡路里的摄入更高,受教育程度也更高。

平均跟踪调查时间为13.5年,在此期间,共出现了3346例房颤诊断。考虑与心脏病相关的其他因素后,新发房颤在每月摄入3次巧克力的人群中比每月不足一次的人群降低10%。在其他摄入量下结果也有差异:每周1次的降低17%,每周2-6次的降低20%,每天至少1次的降低14%。

若按照性别来分析数据,不考虑摄入量,女性的房颤发病率低于男性,但巧克力高摄入量与房颤低风险之间的联系在男性和女性中相同。联系最强的是每周摄入1次的女性(降低21%的风险)和每周摄入2-6次的男性(降低23%的风险)。

这是个观察性研究,所以不能得出关于因果关系的明确结论,加上牛奶可能降低巧克力对心脏健康所起的作用比例。而且通常巧克力会在高卡路里的食物中吃到,这些食物糖和脂肪的含量也很高,而这二者一般对心脏健康没什么好处。

但研究者说:“尽管研究参与者摄入的巧克力中,可能起到保护作用的成分含量不高,但我们仍观察到了统计学上显着的联系。”

有评议对此提出了谨慎的观点,美国北加州的杜克房颤中心的医生认为,这个研究中的巧克力摄入者更健康,受教育程度也更高,这些与更佳的健康状态相关,可能对研究发现产生影响。另外,研究者没有将房颤的其他风险因素纳入考虑,比如肾病和睡眠呼吸暂停。评议还建议,研究仅考虑了房颤的诊断病例,这很难确定巧克力与房颤的低风险相关,还是仅与明显的症状相关。最后,评议补充道,巧克力中可可粉的含量在世界各地不尽相同,所以这个发现在可可粉含量低的国家可能就不适用了。

然而,评论者Drs Sean Polorney和Jonathan Piccini说:“虽然丹麦巧克力研究存在局限性,但研究的发现很有趣,并且值得进一步考虑,尤其是预防房颤的有效措施方面。”


评议出处:Pokorney SD, Piccini JP. Chocolate and prevention of atrial fibrillation: what is bad for the pancreas might be good for the atria? Heart. doi:10.1136/heartjnl-2016-311026

原文出处:Mostofsky E, Berg Johansen M, Tj nneland A, etal. Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study. Heart.doi:10.1136/ heartjnl-2016-310357

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    2017-06-29 zhaojie88
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    2017-06-29 slcumt
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    2017-06-27 清风拂面

    很有趣,巧克力还有这种作用

    0

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    2017-06-27 wyh20044002

    学习了

    0

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心房颤动是重症监护室一种常见的心律失常,胺碘酮是ICU一种常用的抗心律失常药物,但一直缺乏证据指导胺碘酮的临床用药。本研究是一项回顾性研究,研究纳入三级医院外科重症监护室177名有新发房颤的重症患者。胺碘酮的用药(包括剂量和给药时间)以在监护室治疗期间房颤再发次数评估。已知的诱导房颤再发的因素,例如强心药物的应用、本身患有心脏疾病、查而森合并症指数、血清镁离子浓度、液体平衡、血清钾离子浓度等应纳入

JAHA:生命早期危险因素与房颤的相关性研究

早期生命危险因素与心脏代谢疾病有关,但在房颤(AF)方面尚未得到充分研究。 现有的出生体重和房颤的研究结果不一致,母体体重、胎龄、胎盘大小和出生长度的影响是未知的。本研究旨在评估分析早期的生命危险因素与房颤之间的相关性。

J Thorac Cardiovasc Surg:房颤射频消融术后使用胺碘酮:真的有必要吗?一项前瞻性随机对照研究

房颤射频消融术后使用抗心律失常药物目前已经成为习惯用药,但是术后是否用药仍然存在争议。本研究为前瞻性随机对照研究,旨在研究房颤射频消融术后前3个月内使用胺碘酮究竟是否会降低房颤再发率。

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