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Stroke:血压变异性与脑小血管疾病

2019-11-27 xing.T MedSci原创

由此可见,BP变异性较大可能与较高的白质高信号负担增加风险相关。针对较大的BP变异性的治疗策略有可能预防脑小血管疾病,从而降低卒中和痴呆的风险。在未来的研究中应更好地解决潜在的因果关系和脑小血管疾病标志评估中的异质性问题。

血压(BP)变异性可能会增加卒中和痴呆的风险。BP变异性是否与脑小血管疾病(一种常见且可能具有毁灭性的亚临床疾病,会导致卒中和痴呆症)有关,尚无定论。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员将前瞻性队列研究进行系统评价和荟萃分析,这些研究评估了BP变异性与脑小血管疾病已知的标记(包括磁共振成像中的白质高信号、腔隙和微出血)的存在或进展情况之间的关系。

研究人员检索了MEDLINE、EMBASE和Web of Science。十项研究符合定性合成标准,七项研究被纳入荟萃分析。研究人员使用随机效应模型对数据进行合成。

这些研究共计包含2796名受试者,年龄为74(平均)±4(SD)岁,中位随访时间为4.0年。收缩压变异性增加1个SD与白质高信号存在或进展的几率增加相关(比值比为1.26[95%CI为1.06-1.50])。收缩压变异性与腔隙存在(比值比为0.93[95%CI为0.74–1.16])和微出血(比值比为1.13[95%CI为0.89–1.44])之间的相关性无统计学意义。

由此可见,BP变异性较大可能与较高的白质高信号负担增加风险相关。针对较大的BP变异性的治疗策略有可能预防脑小血管疾病,从而降低卒中和痴呆的风险。在未来的研究中应更好地解决潜在的因果关系和脑小血管疾病标志评估中的异质性问题。 

原始出处:

Yuan Ma.et al.Blood Pressure Variability and Cerebral Small Vessel Disease A Systematic Review and Meta-Analysis of Population-Based Cohorts.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026739

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    2019-11-27 心介

    #血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以

    0

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