Lancet Infect Dis：HSV-2感染对HIV感染影响

2019-11-19 MedSci MedSci原创

研究认为，HIV 的巨大负担很可能归因于HSV-2感染。新的预防HSV-2感染干预措施不仅可以减少疱疹性生殖器溃疡疾病的流行，提高数百万人的生活质量，而且还可能对艾滋病毒的传播产生间接影响

2017年对55项前瞻性研究进行的系统回顾和荟萃分析发现，在单纯疱疹病毒2型（HSV-2）感染者中，经调整的HIV感染风险至少增加了三倍。近日研究人员评估了HSV-2感染对HIV发病率的潜在影响。

研究人员使用经典的流行病学公式，考察人口归因分数(PAF)、年龄（15-24岁、25-49岁和15-49岁）、性别和HSV-2感染时间。通过系统回顾和Meta分析，将HSV-2和HIV感染数据与汇总的相对风险(RR)估计相结合，计算出HSV-2感染对HIV感染的影响。

据估计，2016年有140万人因性行为而感染HIV病毒，而年龄在15-49岁之间的人中，有42万人(PAF 29.6%)是由HSV-2感染引起的。非洲地区(PAF：37.1%)、妇女(34.8%)、25-49岁个体(32.4%)和已感染HSV-2 (26.8%)人群中，HSV-2对HIV的影响最大。

研究认为，HIV 的巨大负担很可能归因于HSV-2感染。新的预防HSV-2感染干预措施不仅可以减少疱疹性生殖器溃疡疾病的流行，提高数百万人的生活质量，而且还可能对艾滋病毒的传播产生间接影响。

原始出处：

Katharine J Looker et al. Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence： a population attributable fraction analysis using published epidemiological data.Lancet Infect Dis. November 18，2019.

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2022-12-27 ms6000001411380643 来自广东省

希望国家重视！单纯疱疹要害死人，加快根治药物研究

67 0
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2020-03-18 howi

#Lancet#

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2020-06-25 bnjfx@137.com

#HSV-2#

78 0
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2019-12-17 cmj8wellington

#Dis#

53 0
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2020-06-07 gracezdd

#HSV#

74 0
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2019-11-26 苏小雨

学习了，谢谢分享

113 0
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2019-11-20 yjs木玉

好好好好好好

120 0
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2019-11-19 一个字-牛

学习了谢谢分享

133 0

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