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Stroke：房颤患者福音——新型口服非维生素K拮抗剂抗凝药

2017-10-18 shaosai MedSci原创

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现如今，鲜有在非瓣膜性心房颤动的亚洲人群中比较口服非维生素K拮抗剂抗凝药（NOACs）和华法林的疗效和安全性。本研究旨在比较在韩国心房颤动人群中口服NOACs和华法林的疗效和安全性，尤其是在高危人群中，并将结果发表在Stroke上。

现如今，鲜有在非瓣膜性心房颤动的亚洲人群中比较口服非维生素K拮抗剂抗凝药（NOACs）和华法林的疗效和安全性。本研究旨在比较在韩国心房颤动人群中口服NOACs和华法林的疗效和安全性，尤其是在高危人群中，并将结果发表在Stroke上。本研究数据来自于韩国国家健康保险服务数据库，自2014-2015年中在有心房颤动风险（CHA 2DS 2-VASc score ≥2）的患者中分析NOAC使用者（共有11 611例， 服用利伐沙班者有5681例， 服用达比加群者有3741例， 服用阿哌沙班者有2189例）的缺血性脑卒中、颅内出血（ICH）和全因死亡的风险，并与倾向得分匹配的华法林使用者（n=23 222）进行比较。与华法林相比，NOAC治疗具有相似的缺血性脑卒中风险，ICH和全因死亡率风险较低。在全部NOAC与华法林相比时，具有相似的缺血性脑卒中风险和较低的ICH风险。达比加群和阿哌沙班与华法林相比具有较低的全因死亡率和复合临床预后（缺血性脑卒中、ICH和全因死亡率），然而，利伐沙班与后者比较并无显着性差异。在先前的口服抗凝药的患者（n=23 262）中，达比加群和阿哌沙班在预防ICH中要优

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    2017-10-24 topnew

    好好学习.天天向上.

    0

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    2017-10-20 bsmagic9133

    #维生素K#

    0

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    2017-10-20 智慧医人

    #非维生素K拮抗剂#

    0

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    2017-10-20 zhouqu_8

    #维生素k拮抗剂#

    0

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    2017-10-20 ms5236388012055669

    #拮抗剂#

    0

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    2017-10-20 hittouch

    #房颤患者#

    0

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    2017-10-19 shaosai

    好好学习天天向上

    0

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    2017-10-18 changjiu

    学习了.谢谢

    0

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    2017-10-18 清风拂面

    谢谢分享.学习了

    0

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