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Aust N Z J Psychiatry:发现创伤后应激障碍高危患者潜在影像学标志

2019-04-13 不详 上海交大

近日,上海交通大学医学院附属精神卫生中心王振研究团队与附属仁济医院影像科合作在Australian & New Zealand Journal of Psychiatry杂志在线发表题为Cortical surface area reduction in identification of subjects at high risk for post-traumatic stress disord

近日,上海交通大学医学院附属精神卫生中心王振研究团队与附属仁济医院影像科合作在Australian & New Zealand Journal of Psychiatry杂志在线发表题为Cortical surface area reduction in identification of subjects at high risk for post-traumatic stress disorder:  A pilot study的研究论文,首次报道左侧岛叶、左侧前扣带回喙部皮层表面积小是创伤后应激障碍(Post-traumatic Stress Disorder, PTSD)高危患者的潜在生物学标志,研究将为PTSD早期识别、早期干预提供依据。

PTSD是个体在经历创伤性事件后延迟出现、并持续存在的一种精神障碍。交通事故是日常生活中最常见的创伤性事件,相当一部分经历交通事故者会出现不同程度的心理障碍,其中PTSD是最常见且影响巨大的一种疾病,该病不但治疗难度大,且复发率高,社会功能损害严重。相关研究表明:创伤事件发生后尽早进行临床干预可显着降低PTSD发病率。因此,早期识别、早期干预就对PTSD而言显得意义重大。

该课题组对交通事故伤者进行了磁共振结合临床评估的前瞻性研究,在研究基线纳入交通事故48小时内的伤者,进行磁共振结构像扫描,同时采集临床相关数据。通过6月临床随访,通过临床诊断评估工具,评估PTSD的发生情况。该研究中共70例被试完成临床随访,其中29例伤者发展为PTSD,41例伤者未发展为PTSD。PTSD组被试在交通事故发生时左侧岛叶、左侧前扣带回喙部皮层表面积即显着小于未发展为PTSD的被试。

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