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J Am Acad Dermatol:银屑病与非黑素瘤皮肤癌风险的增加有关

2016-07-22 Mechront 译 MedSci原创

近期有研究表明,女性既往轻微到严重银屑病史与非黑素瘤皮肤癌的风险升高有关,特别是鳞状细胞癌。 研究人员对两个队列研究的数据进行了分析:护士健康研究(NHS)和NHS II。非黑素瘤皮肤癌的诊断,包括鳞状细胞癌(SCC)和基底细胞癌(BCC)。共涉及157934名参与者。NHS队列的63054名参与者中,基线有银屑病史的占1.8%,随访后有1204例SCC和8899例BCC。NHS II队列的

近期有研究表明,女性既往轻微到严重银屑病史与非黑素瘤皮肤癌的风险升高有关,特别是鳞状细胞癌。

研究人员对两个队列研究的数据进行了分析:护士健康研究(NHS)和NHS II。非黑素瘤皮肤癌的诊断,包括鳞状细胞癌(SCC)和基底细胞癌(BCC)。共涉及157934名参与者。NHS队列的63054名参与者中,基线有银屑病史的占1.8%,随访后有1204例SCC和8899例BCC。NHS II队列的94880名参与者中,基线有银屑病史的占1.6%,随访后有521例SCC和7176例BCC。通过银屑病筛查工具证实银屑病的个人病史,并通过补充问卷调查进行验证。

Meta分析结果显示,年龄和多变量调整后的女性SCC的RR值分别为1.56 (95% CI, 1.15-2.12)和1.51 (95% CI, 1.11-2.05),意味着银屑病个人史与SCC风险的升高有关。结果显示银屑病和BCC的风险没有显著相关性。

风险的增加趋势与银屑病的严重程度相关。轻度银屑病组的年龄和多变量调整后的SCC的RR值分别为1.52 (95% CI, 1.01-2.3)和1.42 (95% CI, 0.94-2.15);中度至重度组该数值则分别为1.89 (95% CI, 0.71-5.05)和1.99 (95% CI, 0.74-5.32)(P = .03)。

研究人员总结说:“结果表明,银屑病个人史会增加皮肤癌风险。”

原始出处:

Dai H, et al. Personal history of psoriasis and risk of nonmelanoma skin cancer (NMSC) among women in the United States: A population-based cohort study.J Am Acad Dermatol. 2016;doi:10.1016/j.jaad.2016.05.021.

Psoriasis linked to increased risk for SCC in women.Healio.July 21, 2016

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    2016-10-17 lishizhe
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    2017-01-01 sjq027
  5. [GetPortalCommentsPageByObjectIdResponse(id=1651827, encodeId=1340165182e80, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Mon Oct 17 04:38:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034447, encodeId=79d2203444ef3, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jan 26 12:38:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981015, encodeId=d2ab198101557, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Apr 26 07:38:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061545, encodeId=891120615456b, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jan 01 13:38:00 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479408, encodeId=e82f14e940881, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Sun Jul 24 10:38:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94244, encodeId=0903942446b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:22:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94181, encodeId=b95894181be, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jul 22 20:11:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1651827, encodeId=1340165182e80, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Mon Oct 17 04:38:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034447, encodeId=79d2203444ef3, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jan 26 12:38:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981015, encodeId=d2ab198101557, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Apr 26 07:38:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061545, encodeId=891120615456b, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jan 01 13:38:00 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479408, encodeId=e82f14e940881, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Sun Jul 24 10:38:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94244, encodeId=0903942446b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:22:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94181, encodeId=b95894181be, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jul 22 20:11:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-07-23 oo902

    好好学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1651827, encodeId=1340165182e80, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Mon Oct 17 04:38:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034447, encodeId=79d2203444ef3, content=<a href='/topic/show?id=d17499e79c8' target=_blank style='color:#2F92EE;'>#非黑素瘤皮肤癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99779, encryptionId=d17499e79c8, topicName=非黑素瘤皮肤癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Thu Jan 26 12:38:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981015, encodeId=d2ab198101557, content=<a href='/topic/show?id=3e3fe2073e5' target=_blank style='color:#2F92EE;'>#皮肤癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72073, encryptionId=3e3fe2073e5, topicName=皮肤癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Wed Apr 26 07:38:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061545, encodeId=891120615456b, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Jan 01 13:38:00 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479408, encodeId=e82f14e940881, content=<a href='/topic/show?id=4a571033209b' target=_blank style='color:#2F92EE;'>#黑素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103320, encryptionId=4a571033209b, topicName=黑素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d4d7523220, createdName=yuhaisheng_ibp_32061713, createdTime=Sun Jul 24 10:38:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94244, encodeId=0903942446b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:22:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94181, encodeId=b95894181be, content=学习学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jul 22 20:11:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-07-22 1dd8c52fm63(暂无匿称)

    学习学习!

    0

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