Diabetes Care：外周血干细胞可预测2型糖尿病患者心血管疾病长期预后

2016-11-07 xing.T MedSci原创

由此可见，2型糖尿病患者循环中CD34+干细胞基础水平降低，可以预测6年后不良心血管事件的预后，并改善心血管疾病危险分层。

糖尿病患者心血管疾病的风险存在很大的变异性，生物标志物可以改善糖尿病患者心血管疾病的风险分层。有研究表明外周血干细胞可以预测心血管事件和死亡情况，但在糖尿病患者中此项数据是很少的。近日，糖尿病领域权威杂志Diabetes Care发表了一篇研究文章，在这项研究中，研究人员评估了外周血干细胞水平预测心血管疾病预后和改善2型糖尿病患者心血管疾病危险分层的能力。

研究者对187例2型糖尿病患者进行了6.1年的随访，主要结局事件是第一次发生心血管事件的时间，该指标中的心血管事件具体可以定义为3种主要的不良心血管事件（心血管死亡、非致死性心肌梗死或非致死性卒中）和因心血管疾病导致的住院。在研究之初，研究人员测量了外周血里表达CD34、CD133和KDR的六种表型的干/祖细胞的水平。

48例（4.5/100例病人/年）糖尿病患者发生主要结局事件，相比于没有CD34+细胞和CD34+/CD133+细胞的糖尿病患者，含有CD34+细胞和CD34+/CD133+细胞的糖尿病患者心血管事件的发生率显著降低。在含有CD34+细胞和CD34+/CD133+细胞水平位于中位水平以下的糖尿病患者，其心血管事件发生率较高。研究者通过Cox比例风险回归分析发现，降低的CD34+细胞（风险比为2.21，95%可信区间为1.14–4.29）和CD34+/CD133+细胞（风险比为2.98，95%可信区间为1.46–6.08）计数可以独立预测心血管事件的发生。

由此可见，2型糖尿病患者循环中CD34+干细胞基础水平降低，可以预测6年后不良心血管事件的预后，并改善心血管疾病危险分层。

原始出处：

Gian Paolo Fadini,et al. Long-term Prediction of Cardiovascular Outcomes by Circulating CD34+ and CD34+CD133+ Stem Cells in Patients With Type 2 Diabetes. Diabetes Care. 2016 Nov; dc161755. http://dx.doi.org/10.2337/dc16-1755

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2017-02-27 木头人513

#Diabetes#

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2017-10-10 ymljack

#长期预后#

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2017-09-10 ms5439512287675881

#BET#

47 0
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2017-04-13 ms9608593228839890

#DIA#

59 0
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2016-11-10 laoli

谢谢分享！学习了！

99 0
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2016-11-10 1dedfe95m66(暂无匿称)

又是CD34+

113 0
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encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
2016-11-09 aids213

#2型糖尿病患者#

60 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:41:31 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383264, encodeId=bacc1383264c6, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474089, encodeId=c34e14e4089ea, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498086, encodeId=8f30149808624, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578521, encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
2016-11-09 xue8604

#糖尿病患者#

50 0
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topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Apr 13 23:34:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154853, encodeId=16c315485391, content=谢谢分享！学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Nov 10 17:28:10 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154789, encodeId=da5f154e89b7, content=又是CD34+, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:41:31 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383264, encodeId=bacc1383264c6, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474089, encodeId=c34e14e4089ea, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498086, encodeId=8f30149808624, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578521, encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
2016-11-09 andy2090

#血管疾病#

57 0
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objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498086, encodeId=8f30149808624, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578521, encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
2016-11-09 ms3994565386320060

#外周血#

55 0

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Diabetes Care：外周血干细胞可预测2型糖尿病患者心血管疾病长期预后

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