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CLIN CANCER RES：肿瘤PD-L2表达：与肿瘤抗PD-1治疗的关系

2017-07-04 MedSci MedSci原创

PD-L2PD-L1免疫治疗
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肿瘤相关PD-L1表达可以预测PD-1免疫治疗的临床效果。PD-L1阴性患者同样会对PD-1免疫检查点抑制产生反应，表明其他PD-1配体与这些治疗的临床效果有关。PD-L2是另一种已知的PD-1配体。CLIN CANCER RES近期发表了一篇文章，研究PD-L2与抗PD-1治疗反应之间的关系。

肿瘤相关PD-L1表达可以预测PD-1免疫治疗的临床效果。PD-L1阴性患者同样会对PD-1免疫检查点抑制产生反应，表明其他PD-1配体与这些治疗的临床效果有关。PD-L2是另一种已知的PD-1配体。CLIN CANCER RES近期发表了一篇文章，研究PD-L2与抗PD-1治疗反应之间的关系。

作者使用免疫组化的方法检测肿瘤组织中PD-L2表达。评估接受过pembrolizumab治疗的复发或转移头颈部鳞状细胞癌（HNSCC）患者肿瘤组织PD-L2表达与临床反应之间的关系。研究发现所有类型肿瘤均表达PD-L2。PD-L2分布与PD-L1显着相关。在某些缺乏PD-L1的肿瘤中检测到PD-L2表达。PD-L1及PD-L2均可以预测pembrolizumab治疗反应。PD-L1与PD-L2均为阳性的患者治疗反应比仅PD-L1阳性的患者更好。PD-L2也是pembrolizumab治疗无进展生存（PFS）的独立预测员因素。与PD-L2阴性患者相比，PD-L2阳性患者无进展生存及总生存时间更长。

文章最后认为，HNSCC患者pembrolizumab治疗反应与PD-L1/PD-L2阻断相关。对于这部分患者，靶向两种PD-1配体可以有良好的临床获益。

原始出处：
Jennifer H.Yearley,Christopher Gibson,et al.PD-L2 Expression in Human Tumors:Relevance to Anti-PD-1 Therapy in Cancer.CLIN CANCER RES.June 2017 doi:10.1158/1078-0432.CCR-16-1761

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    2017-08-15 wushaoling

    #PD-L2#

    0

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    2017-07-09 大爰

    学习了谢谢分享！！

    0

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    2017-07-06 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

    0

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    2017-07-05 清风拂面

    谢谢分享学习，受益匪浅

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1649476, encodeId=a95616494e649, content=<a href='/topic/show?id=c18f1393252' target=_blank style='color:#2F92EE;'>#PD-L2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13932, encryptionId=c18f1393252, topicName=PD-L2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38d523833480, createdName=wushaoling, createdTime=Tue Aug 15 15:25:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220156, encodeId=b2a5220156f9, content=学习了谢谢分享！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Jul 09 06:17:55 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219015, encodeId=fb48219015e2, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jul 06 06:38:57 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218832, encodeId=b68d2188325d, content=谢谢分享学习，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Jul 05 14:21:46 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218706, encodeId=8e4e218e069e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Jul 05 07:11:19 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218704, encodeId=745d218e04b0, content=非常好的文章，学习了，很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jul 05 07:04:13 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218640, encodeId=19ee21864047, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Jul 05 00:33:24 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 hfuym10906

    学习了

    0

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    2017-07-05 天涯183

    非常好的文章，学习了，很受益

    0

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    2017-07-05 184****9840

    学习了谢谢分享

    0

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