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Heart:阵发性房颤患者更少使用抗凝药治疗

2017-09-26 王淳 环球医学

2017年10月,发表在《Heart》的一项由英国科学家进行的研究,考察了英国初级医疗机构阵发性房颤的治疗情况,发现阵发性房颤(AF)患者是否比持续性/永久性AF患者使用抗凝药治疗的可能性低。



2017年10月,发表在《Heart》的一项由英国科学家进行的研究,考察了英国初级医疗机构阵发性房颤的治疗情况,发现阵发性房颤(AF)患者是否比持续性/永久性AF患者使用抗凝药治疗的可能性低。

目的:旨在确定阵发性AF患者是否比持续性/永久性AF患者使用抗凝药治疗的可能性低,并考察2000~2015年的治疗趋势。英国和欧洲指南建议,不论AF类型如何,所有卒中风险增加的AF患者都要接受抗凝治疗。

方法:2000~2015年每年的5月1日进行了16项序贯横断面分析。数据来源为英国648个初级医疗机构的初级医疗数据,构成了健康改进网络数据库。所有确诊为AF的≥35岁且注册至少1年的患者都纳入到本研究中。主要结局测量为抗凝药的处方。

结果:确诊为阵发性AF的患者比例从2000年的7.4%(95% CI,7.0~7.8)增加到2015年的14.0%(13.7~14.3)。CHADS2评分≥1的患者中,阵发性AF和其他(持续性/永久性)AF患者2000~2015年的抗凝药处方比例分别从18.8%(16.4~21.4)增加到56.2%(55.0~57.3)和从34.2%(33.3~35.0)增加到69.4%(68.9~69.8)。阵发性AF vs其他AF患者治疗的相对风险(RR)从0.48(0.42~0.55)增加到0.76(0.74~0.77)。调整年龄、性别、汤森德评分、禁忌症的存在与否等,对结果几乎没有影响。

结论:2000年,符合条件的阵发性AF患者接受抗凝治疗的可能性是其他AF患者的一半;随着时间发展,此现象有所改善,但是2015年,符合条件的阵发性AF患者抗凝药处方的可能性仍然低约20%。

原始出处

Isaew A, Adderley NJ, Ryan R, et al. The treatment of paroxysmal atrial fibrillation in UK primary care. Heart. 2017 Oct;103(19):1502-1507. doi: 10.1136/heartjnl-2016-310927. Epub 2017 Jun 1.

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    2017-09-28 zhaojie88
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    2017-09-28 slcumt
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    2017-09-26 1e0f8808m18(暂无匿称)

    阵发性房颤.抗凝治疗也很重要的.

    0

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    2017-09-26 楠博One

    容易引起血栓

    0

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