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Eur J Gastroenterol Hepatol:非酒精性脂肪性肝病患者的认知评估

2018-04-11 MedSci MedSci原创

研究结果显示,NAFLD患者可能有早期或轻微的认知功能障碍,包括在视觉空间和执行功能领域。还需进一步的有针对性的心理测试,以确认这一人群的认知障碍的存在。

研究目的:本研究的目的是采用蒙特利尔认知评估(MoCA),研究非酒精性脂肪肝(NAFLD)患者认知表现。

研究方法:在这项前瞻性的横断面研究中,共有70例NAFLD和73例年龄匹配和性别匹配的健康参与者参加了这项研究。通过腹部超声检查判定是否存在NAFLD。计算人体测量指标,并对每个参与者进行了常规的实验室分析。所有参与者都提供了社会人口统计学数据。使用土耳其版的MoCA对认知功能进行评估,评分低于21分判定为轻度认知障碍。

研究结果:NAFLD患者的MoCA评分明显低于健康组(P<0.05)。此外,相比健康参与者,NAFLD患者呈现出视觉空间和执行功能的损害(P<0.05,分别)。在多元模型中,教育水平[2.79 (1.12-6.96);P<0.05)和居住面积[5.68 (2.24-14.38);P<0.001与NAFLD患者和健康参与者的认知功能障碍独立相关。在NAFLD患者中,MoCA评分与纤维化4期呈负相关(r=-0.359;P < 0.05)。然而,在NAFLD组,肝脂肪变性分级和代谢综合征的存在与MoCA评分不相关(P>0.05)。

研究结论:研究结果显示,NAFLD患者可能有早期或轻微的认知功能障碍,包括在视觉空间和执行功能领域。还需进一步的有针对性的心理测试,以确认这一人群的认知障碍的存在。

原始出处:


Celikbilek A, Celikbilek M, Bozkurt G, et al. Cognitive assessment of patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol, 2018.doi: 10.1097/MEG.0000000000001131.

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    2018-07-21 qjddjq
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    2018-11-13 许安
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
  9. 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href='/topic/show?id=1e1584351b2' target=_blank style='color:#2F92EE;'>#脂肪性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84351, encryptionId=1e1584351b2, topicName=脂肪性肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46224431741, createdName=wwzzly, createdTime=Fri Nov 30 10:22:00 CST 2018, time=2018-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427076, encodeId=7117142e076aa, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Apr 13 10:22:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
    2018-04-13 gwc384
  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304851, encodeId=422c304851d3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 11 19:26:31 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
    2018-04-11 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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