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IBD:IL-9可以预测克罗恩病疾病活动度并且判断英夫利西单抗的疗效

2017-10-27 许奕晗 MedSci原创

血清中IL-9水平的升高能够反应肠道的炎症情况,但是其在克罗恩病CD中的作用还不明确。作者试图分析IL-9血清学水平与CD患者疾病活动度之间的关系,希望能够用IL-9来预测英夫利西单抗在治疗CD中的疗效。

血清中IL-9水平的升高能够反应肠道的炎症情况,但是其在克罗恩病CD中的作用还不明确。作者试图分析IL-9血清学水平与CD患者疾病活动度之间的关系,希望能够用IL-9来预测英夫利西单抗在治疗CD中的疗效。

作者在2013年1月至2015年12月招募了100名CD患者和50名年龄、性别相匹配的对照个体,使用酶联免疫吸附法测定其IL-9水平,检查血清IL-9水平与疾病严重程度之间的相关性。其中30名患者进行了英夫利西单抗治疗,IL-9水平用来预测患者粘膜愈合情况。

本项研究结果显示:活动期CD患者的血清IL-9水平要明显高于对照组(22.0 pg / mL VS 6.3 pg / mL),并且其浓度与疾病的严重程度成正比,而使用英夫利西单抗治疗的患者其在第30周是IL-9水平基本可以达到正常值。

通过此项研究我们发现,血清IL-9水平与CD疾病严重程度和IFX在CD患者中的临床疗效相关,IL-9可能是检测CD病情的新型生物标志物。

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    2017-10-29 bnurmamat
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