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Eur Respir J:阻塞性睡眠呼吸暂停不是住院抑郁症发生的危险因素!

2017-06-18 xing.T MedSci原创

在一个大型的疑似OSA的临床队列中,控制混杂因素后,OSA症状和严重程度均与住院抑郁症的发生风险不相关,表明先前报道的OSA与抑郁症之间的相关性可能是由于重叠的诊断标准所致。然而,该研究的发现不能排除OSA和轻度抑郁症之间的潜在的联系。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在评估阻塞性睡眠呼吸暂停(OSA)是否与住院抑郁症的发病有关,住院抑郁症作为一个强大的终点是不太可能导致误诊。

在1994至2010年间,研究人员将所有可疑的成年OSA患者转诊至一所大型城市教学医院接受诊断性睡眠呼吸暂停检查,并且在1991年至2015年间与省级卫生管理数据进行链接。研究人员采用Cox回归分析调查OSA症状以及严重程度与主要结局住院抑郁症发生之间的相关性。

在中位随访9.7 年,10 149名参与者中的136名(1.3%)患者发生住院抑郁症。OSA症状(醒来不清醒以及影响记忆力和注意力)对住院抑郁症具有粗略的显著效应,在控制了混杂因素后变得不显著了。呼吸暂停低通气指数与结局并不存在显著相关:调整后的风险比(33 vs. 6 事件/小时)为1.13(95%可信区间为0.91-1.40)。与住院抑郁症相关的因素包括女性、年龄较小、使用安眠药、酗酒和失业。

在一个大型的疑似OSA的临床队列中,控制混杂因素后,OSA症状和严重程度均与住院抑郁症的发生风险不相关,表明先前报道的OSA与抑郁症之间的相关性可能是由于重叠的诊断标准所致。然而,该研究的发现不能排除OSA和轻度抑郁症之间的潜在的联系。

原始出处:


Tetyana Kendzerska,et al. Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study. Eur Respir J. http://erj.ersjournals.com/content/49/6/1601361

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    2017-08-08 tomyang96
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    2017-06-19 清风拂面

    谢谢分享,学习了

    0

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    2017-06-19 tanxingdoctor

    谢谢分享!学习啦!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1989043, encodeId=3419198904342, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Tue May 22 15:01:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696731, encodeId=179e1696e3180, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Aug 08 05:01:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596491, encodeId=3ec9159649188, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Tue Jun 20 12:01:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212585, encodeId=10a321258526, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 19 07:03:36 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212523, encodeId=f19021252399, content=谢谢分享!学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Jun 19 01:06:17 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212518, encodeId=adcf21251852, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Jun 19 00:55:49 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212452, encodeId=42a3212452e6, content=在一个大型的疑似OSA的临床队列中,控制混杂因素后,OSA症状和严重程度均与住院抑郁症的发生风险不相关,表明先前报道的OSA与抑郁症之间的相关性可能是由于重叠的诊断标准所致。然而,该研究的发现不能排除OSA和轻度抑郁症之间的潜在的联系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jun 18 22:23:16 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-19 130****4638

    学习了谢谢分享。

    0

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    2017-06-18 有备才能无患

    在一个大型的疑似OSA的临床队列中,控制混杂因素后,OSA症状和严重程度均与住院抑郁症的发生风险不相关,表明先前报道的OSA与抑郁症之间的相关性可能是由于重叠的诊断标准所致。然而,该研究的发现不能排除OSA和轻度抑郁症之间的潜在的联系。

    0

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