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Stroke:老年睡眠呼吸暂停患者卒中发病率增加

2018-12-14 xing.T MedSci原创

由此可见,在未治疗的严重OSA的老年患者中,卒中发生率而非冠心病发病率有所增加。适当的CPAP治疗可以降低这种风险。

年龄对阻塞性睡眠呼吸暂停(OSA)与血管事件发生率之间关系的影响仍存在争议。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员试图分析一大群老年患者OSA与卒中和冠心病发病率之间的关系,以及研究持续气道正压通气(CPAP)治疗在这些关联中的作用。

研究人员对2个西班牙大学医院中连续就诊的怀疑为OSA的≥65岁的患者中进行的前瞻性观察研究进行了事后分析。呼吸暂停-低通气指数(AHI)<15的患者为对照组。OSA定义为AHI≥15并归类为未治疗(未接受CPAP或依从性<4小时/天),轻度-中度(AHI为15-29),未治疗的严重(AHI≥30)和CPAP治疗(AHI≥15和CPAP依从性≥4小时/天)的患者。

859名和794名老年患者分别被纳入卒中和冠心病分析。随访时间中位数(四分位数间)分别为72(50-88.5)和71(51.5-89)个月。与对照组相比,未治疗的严重OSA组、CPAP治疗组和未治疗的轻度-中度OSA组患者卒中发生率的完全调整风险比分别为3.42(95%CI为1.37-8.52)、1.02(95%CI为0.41-2.56)和1.76(95%CI为0.62-4.97)。在其他不同的OSA组中未观察到与冠心病发病率之间存在关联。

由此可见,在未治疗的严重OSA的老年患者中,卒中发生率而非冠心病发病率有所增加。适当的CPAP治疗可以降低这种风险。

原始出处:

Pablo Catalan-Serra,et al.Increased Incidence of Stroke, but Not Coronary Heart Disease, in Elderly Patients With Sleep Apnea Role of Continuous Positive Airway Pressure Treatment.Stroke. 2018.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023353

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    2018-12-19 jyzxjiangqin

    老年睡眠呼吸暂停患者。

    0

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    2018-12-14 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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