Baidu
map

Nature :研究确定类风湿关节炎40多个遗传风险基因

2014-01-02 佚名 生物谷

近日,发表在Nature杂志上的一项荟萃分析,确定了与类风湿关节炎相关的42个新的遗传基因,有助于更好地治疗自身免疫性疾病。【原文下载】 世界范围内,每一百个人中就有一人患类风湿关节炎,根据世界卫生组织的估计。大约有一半的成年人在自身免疫性疾病诊断的10年内都无法全职工作。 新研究对10万多个体基因数据进行荟萃分析,一个重要的发现是,参与心血管疾病的一些基因变异与参与癌症和类风湿关节炎的基因重

近日,发表在Nature杂志上的一项荟萃分析,确定了与类风湿关节炎相关的42个新的遗传基因,有助于更好地治疗自身免疫性疾病。【原文下载

世界范围内,每一百个人中就有一人患类风湿关节炎,根据世界卫生组织的估计。大约有一半的成年人在自身免疫性疾病诊断的10年内都无法全职工作。

新研究对10万多个体基因数据进行荟萃分析,一个重要的发现是,参与心血管疾病的一些基因变异与参与癌症和类风湿关节炎的基因重叠。

主要研究人员Siminovitch博士说:我们可以利用这些知识来找出疾病的分子途径,以及找到能有效对抗类风湿性关节炎的已有药物(例如治疗心血管疾病的药物)。此外,还可以用这个研究中的遗传信息数据开展个性化治疗。

原文出处

Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao,Katsunori Ikari,Yuta Kochi, Koichiro Ohmura,Akari Suzuki,  Shinji Yoshida,Robert R. Graham,Arun Manoharan, Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler, Jeffrey D. Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye, Ding-Feng Su,jian Yang et al.Genetics of rheumatoid arthritis contributes to biology and drug discovery.Nature  07 November 2013 【原文下载

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]
    2014-04-16 一叶知秋
  2. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]
    2014-01-04 lmm397
  3. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1879826, encodeId=4fb018e9826d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Apr 16 00:06:00 CST 2014, time=2014-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265182, encodeId=130612651825f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333749, encodeId=59381333e4963, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361905, encodeId=282513619051f, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442673, encodeId=581414426e3bc, content=<a href='/topic/show?id=75a51008e363' target=_blank style='color:#2F92EE;'>#风险基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100873, encryptionId=75a51008e363, topicName=风险基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cf64946767, createdName=12498cbcm01(暂无昵称), createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597220, encodeId=cf89159e220d0, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 04 04:06:00 CST 2014, time=2014-01-04, status=1, ipAttribution=)]

相关资讯

类风湿关节炎发病机制有新解

北京大学人民医院研究人员在类风湿关节炎患者体内发现了一种新型免疫细胞——前体滤泡辅助性T细胞(pTfh),这种细胞在引起类风湿关节炎等自身免疫病的发病机制中起关键性作用,如果靶向性抑制pTfh细胞,阻断疾病的发生发展,有可能成为自身免疫病治疗的新途径。相关论文日前发表在国际杂志《免疫》上。这是该院风湿免疫科栗占国教授牵头的国家“973”计划项目的最新成果。 类风湿关

Nature:大规模研究发现类风湿关节炎的大量新基因线索

26 日,一个由美国、日本、法国、中国等国组成的国际研究小组发现 40 多个新的 DNA 区域会增加类风湿性关节炎的风险。这项工作是迄今为止开展的最大规模的基因研究,涉及近 3 万名患者。研究者相信,他们可以研发新的针对类风湿性关节炎的药物,也许有一天能够彻底治愈这一疾病。该研究结果发表在最新一期《自然》(Nature)杂志上。 该科研小组比较了关节炎患者的 DNA 和那些没有这

Ann Rheum Dis:瓜氨酸化的纤维蛋白会加剧类风湿关节炎的炎症反应

在RA早期病程中,抗瓜氨酸抗体(ACPA)和瓜氨酸化纤维蛋白原抗体(ACF)的出现预示着关节炎症较抗体阴性的患者将更加严重。纤维蛋白在关节局部的沉积是类风湿关节炎(RA)的病理特点之一,与早期病程的发病机制和病情的严重程度都密切相关。尤其当这些纤维蛋白一旦经瓜氨酸化,即可成为ACPA的自身抗原而进一步触发RA的发生。来自瑞士苏黎世大学实验风湿病学中心的Olga Sanchez-Pernaute等研

Arth CR:超声可以评估类风湿关节炎的活动程度

苏格兰的研究者发现,结合肌肉骨骼超声检查对疾病的活动程度进行评估,可以指导早期类风湿性关节炎的治疗选择。据格拉斯哥大学的James Dale(内外全科医学士,MBChB)及其同事介绍,在所有的临床评价中,有29%进行了肌肉骨骼超声检查,而据此获得的超声影像学结果,为是否应该调整DMARD(缓解疾病的抗风湿性药物)的治疗方案提供了相关的信息。研究人员在一月份的《关节炎治疗与研究》的杂志中表示,举例来

PLOS Pathogens :研究发现牙周病和类风湿关节炎之间的关联机制

出现牙龈疾病是否表示将来会有关节问题?虽然研究人员和临床医生们早就知道这两个流行慢性炎症性疾病--牙周病和类风湿关节炎(RA)之间存在一定的关联,但其中微生物的机制仍不清楚。 发表在PLoS Pathogens杂志上的新研究论文中,路易斯维尔(肯塔基州)学校牙科口腔健康和全身疾病组研究员Jan Potempa博士和来自欧盟牙龈和关节项目组的科学家已经发现了引发牙周疾病的细菌--卟啉单胞菌属,如何

Ann Rheum Dis:不宜过早撤去甲氨蝶呤

加拿大一项研究表明,对甲氨蝶呤(MTX)反应不佳的类风湿关节炎(RA)患者,用依那西普(ETN)+甲氨蝶呤(MTX)连续治疗6个月后,与继续联用两种药物的患者相比,撤去MTX的患者在6~12个月间未获同等程度的改善。论文8月26日在线发表于《风湿病学年鉴》(Ann Rheum Dis)杂志。  研究纳入205例符合①未接受肿瘤坏死因子抑制剂治疗,②尽管接受持续的MTX治疗,但疾病活动度评分(DAS

Baidu
map
Baidu
map
Baidu
map