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SCI REP：血清乙型肝炎核心抗体作为ALT正常的慢性乙型肝炎患者肝脏炎症标志物！

2017-06-05 xing.T MedSci原创

抗-HBcALT乙肝肝脏炎症标志物
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由此可见，抗-HBc可能是评估肝脏炎症的程度的重要指标，其可用于ALT水平正常的慢性乙型肝炎患者进行抗病毒治疗的决策。

研究人员既往的研究表明血清乙肝核心抗体（抗-HBc）水平与血清丙氨酸氨基转移酶（ALT）水平呈正相关。近日，Scientific reports 杂志上发表了一篇研究文章，该研究的目的是确定慢性乙型肝炎患者中抗-HBc能否作为检测肝脏炎症的生物标志物，尤其是在ALT水平正常的患者中。

研究人员测定并量化了655名未接受治疗的慢性乙型肝炎患者血清中抗-HBc水平，其中45例进行了肝脏活检（分别在基线期和抗病毒治疗后第七十八周）。

研究人员发现血清抗-HBc水平明显增加，并且组织活动指数（HAI）评分也一起增加。在进行抗病毒治疗后，HAI评分分数减少的患者血清中抗-HBc水平显著下降。多因素分析显示ALT水平正常的患者中抗-HBc抗体与中至中度肝脏炎症独立相关。此外，在乙肝e抗原（HBeAg）阳性和HBeAg阴性且ALT水平正常的慢性乙型肝炎患者中，血清抗-HBc水平对预测中至重度肝脏炎症显示出了较高的诊断准确性（曲线下面积AUC 分别为0.87和0.75）。

由此可见，抗-HBc可能是评估肝脏炎症的程度的重要指标，其可用于ALT水平正常的慢性乙型肝炎患者进行抗病毒治疗的决策。

原始出处：

Jiyuan Zhou,et al. Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-03102-3

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    2018-01-05 hukaixun

    #标志物#

    0

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    2017-12-31 shizhenshan

    #ALT#

    0

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    2017-12-26 okhuali

    #乙型肝炎#

    0

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13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207690, encodeId=df0620e690db, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Jun 07 11:46:44 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-12-21 ms7405317358118777

    #炎症标志物#

    0

  5. 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    2017-11-26 huiwelcome

    #肝炎患者#

    0

  6. 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    2017-06-08 ylzr123

    认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。给点赞啦

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jun 08 09:33:29 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207759, encodeId=b25020e759ca, content=以后就有依据了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa562069713, createdName=1361efd61am, createdTime=Wed Jun 07 15:38:13 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529598, encodeId=a1ee1529598df, content=<a href='/topic/show?id=e1c0814517e' target=_blank style='color:#2F92EE;'>#肝脏炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81451, encryptionId=e1c0814517e, topicName=肝脏炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0e11959960, createdName=zsyan, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271247, encodeId=61f512e124796, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207690, encodeId=df0620e690db, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Jun 07 11:46:44 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 1361efd61am

    以后就有依据了。

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jun 08 09:33:29 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207759, encodeId=b25020e759ca, content=以后就有依据了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa562069713, createdName=1361efd61am, createdTime=Wed Jun 07 15:38:13 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529598, encodeId=a1ee1529598df, content=<a href='/topic/show?id=e1c0814517e' target=_blank style='color:#2F92EE;'>#肝脏炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81451, encryptionId=e1c0814517e, topicName=肝脏炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0e11959960, createdName=zsyan, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271247, encodeId=61f512e124796, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207690, encodeId=df0620e690db, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Jun 07 11:46:44 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 zsyan

    #肝脏炎症#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1841021, encodeId=bbbe184102187, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jan 05 04:56:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861099, encodeId=57ab18610991e, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jun 08 09:33:29 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207759, encodeId=b25020e759ca, content=以后就有依据了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa562069713, createdName=1361efd61am, createdTime=Wed Jun 07 15:38:13 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529598, encodeId=a1ee1529598df, content=<a href='/topic/show?id=e1c0814517e' target=_blank style='color:#2F92EE;'>#肝脏炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81451, encryptionId=e1c0814517e, topicName=肝脏炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0e11959960, createdName=zsyan, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271247, encodeId=61f512e124796, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207690, encodeId=df0620e690db, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Jun 07 11:46:44 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 guguangxiang

    #慢性乙型肝炎#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1841021, encodeId=bbbe184102187, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jan 05 04:56:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861099, encodeId=57ab18610991e, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Jun 08 09:33:29 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207759, encodeId=b25020e759ca, content=以后就有依据了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa562069713, createdName=1361efd61am, createdTime=Wed Jun 07 15:38:13 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529598, encodeId=a1ee1529598df, content=<a href='/topic/show?id=e1c0814517e' target=_blank style='color:#2F92EE;'>#肝脏炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81451, encryptionId=e1c0814517e, topicName=肝脏炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0e11959960, createdName=zsyan, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271247, encodeId=61f512e124796, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jun 07 13:56:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207690, encodeId=df0620e690db, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Jun 07 11:46:44 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 往日如昨

    继续学习中谢谢

    0

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