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注意!糖尿病常用药新增5种 效果更好副作用还小!

2017-04-02 张 赫 健康时报

国家新医保药品目录中,糖尿病药物今年新增了7种,5种为新品种。这五种药物分别为阿格列汀、利格列汀、沙格列汀、维格列汀、西格列汀,它们都是DPP-4抑制剂。


国家新医保药品目录中,糖尿病药物今年新增了7种,5种为新品种。这五种药物分别为阿格列汀、利格列汀、沙格列汀、维格列汀、西格列汀,它们都是DPP-4抑制剂。与二甲双胍这种常用的糖尿病口服药相比,治疗效果更好、副作用风险更低。

一份《市售DPP-4抑制剂类抗糖尿病药物的比较研究》曾公开了对这个糖尿病口服药新品种的长期统计结果:大部分DPP-4抑制剂在人体内的口服利用率均高于一般药品,其中西格列汀达87%,是一般口服药物的2~3倍。余下药物,维格列汀约为85%,阿格列汀约为70%。

由于极高的利用率,DPP-4抑制剂只需每日服用一次,就能达到与其他药物日服三次的效果。

北京中医药大学东方医院药剂科主任郑飞介绍,DPP-4抑制剂可以在一定程度上降低心脏收缩压。特别是西格列汀,有助于促进激素分泌,降低血液中脂肪酸浓度,从而实现降低餐后血脂。

解放军火箭军总医院内分泌科主任李全民说,没进医保目录之前,DPP-4抑制剂价格偏贵,日均花费在8~11元左右,让很多患者望而却步。现在它们进了医保,也算是“贵族药”送进了百姓家。

虽然DPP-4抑制剂优势不少,但在服用时也有禁忌。复旦大学附属华山医院内分泌科副主任医师吴曦说,5种DPP-4抑制剂中,除了利格列汀,都是通过肾脏代谢,中度或者严重的肾功能不全的糖尿病患者,剂量应做相应调整,大概为常规用量的1/2或1/4。吴曦医师对全国的糖尿病患者是否能即时买到这五种药持保留态度,他表示:“各省市医院采购药品都有自主权,并非所有医保目录中的药物都可以被采购到地方医院,所以想要糖尿病患者都能买到DPP-4抑制剂,还需要一个调整的过程。”

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    2017-12-23 showtest
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    2017-04-03 lyh994

    是药三分毒是谁说的?

    0

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    2017-04-03 tofsw

    学习了谢谢分享

    0

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    2017-04-02 1e10eabem79(暂无匿称)

    又给糖尿病带来了更多选择

    0

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    2017-04-02 lemon985

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