Hepatology：EBR/GZR联合SOF治疗HCV基因3型代偿性肝硬化患者初治和经治患者疗效良好

2018-03-17 MedSci MedSci原创

HCV GT3感染和肝硬化患者表现出较高的疗效。超过12周的治疗是不需要的，而且不论基线RASs如何，直接抗病毒疗效都维持不变。本研究的表明，EBR/GZR联合SOF治疗HCV基因3型代偿性肝硬化患者初治和经治患者疗效良好

研究背景：直接抗病毒治疗药物治疗HCV患者，疗效显著、安全性较好。本研究的目的是评估elbasvir/grazoprevir (EBR/GZR)+ 索非布韦(SOF)联合利巴韦林(RBV)或不联合利巴韦林(RBV)治疗HCV 基因3型代偿性肝硬化患者的效果。

研究方法：本研究为2期、随机、开放标签研究。初治患者接受EBR/GZR + SOF + RBV治疗8周或接受EBR/GZR + SOF治疗12周；聚乙二醇干扰素/RBV经治的患者，接受EBR/GZR + SOF +/- RBV治疗12周或EBR/GZR + SOF治疗16周。研究主要终点为治疗结束后12周，血清HCV RNA <15 IU/mL。

研究结果：接受EBR/GZR + SOF + RBV治疗8周，未治患者SVR12为91% (21/23)；接受EBR/GZR + SOF治疗12周，未治患者SVR12为96% (23/24)。接受EBR/GZR + SOF - RBV治疗12周、EBR/GZR + SOF +RBV治疗12周和EBR/GZR + SOF治疗16周的患者，SVR12分别为94% (17/18)、100% (17/17)、94% (17/18)。5例参与者未能获得SVR，2例患者发生HCV复发（都出现在8周治疗组），1例因呕吐/蜂窝织炎而中断（16周治疗组），2例停止治疗(同意撤回/失去后续行动)。SVR12不受耐药相关替代(RASs)的影响。胰岛素抵抗没有持续的变化，5名参与者报告严重的不良反应(肺炎、胸痛、阿片过量、细胞炎、肌酐减少)。

研究结论：HCV GT3感染和肝硬化患者表现出较高的疗效。超过12周的治疗是不需要的，而且不论基线RASs如何，直接抗病毒疗效都维持不变。本研究的表明，EBR/GZR联合SOF治疗HCV基因3型代偿性肝硬化患者初治和经治患者疗效良好。

原始出处

Foster GR， Agarwal K， Cramp ME， et al. Elbasvir/Grazoprevir and Sofosbuvir for HCV Genotype 3 Infection With Compensated Cirrhosis： A Randomized Trial. Hepatology， 2018， Feb 23. doi： 10.1002/hep.29852.

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2018-09-09 ms5106640509429053

#代偿性肝硬化#

71 0
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2018-05-30 pyaili

#经治患者#

60 0
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2018-03-19 ymljack

#HCV#

57 0
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2018-03-19 gwc384

#EPA#

74 0
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2018-03-17 有备才能无患

直接抗病毒治疗药物治疗HCV患者.疗效显著.安全性较好.本研究的目的是评估elbasvir/grazoprevir(EBR/GZR)+索非布韦(SOF)联合利巴韦林(RBV)或不联合利巴韦林(RBV)治疗HCV基因3型代偿性肝硬化患者的效果.

88 0
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2018-03-17 九九消寒

优质资源.共同学习

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Hepatology：EBR/GZR联合SOF治疗HCV基因3型代偿性肝硬化患者初治和经治患者疗效良好

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