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Oncotarget：α亚麻酸可抑制缺氧微环境具有抗癌作用

2017-10-21 MedSci MedSci原创

缺氧微环境α亚麻酸线粒体凋亡脂肪酸
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α-亚麻酸是必需的多不饱和脂肪酸，据研究报道具有抗癌潜力，但是并没有明确的假设或机制。本研究旨在验证α亚麻酸体外和体内对线粒体凋亡、缺氧微环境和脂肪酸合成的影响。对于ER + MCF-7细胞，α亚麻酸的IC 50值为17.55μM。吖啶橙/溴化乙锭和JC-1染色研究发现，α-亚麻酸处理后，早期和晚期凋亡信号以及线粒体去极化明显存在。α-亚麻酸使得细胞周期停滞在G2/M期。随后，研究人员探究了体内α

α-亚麻酸是必需的多不饱和脂肪酸，据研究报道具有抗癌潜力，但是并没有明确的假设或机制。本研究旨在验证α亚麻酸体外和体内对线粒体凋亡、缺氧微环境和脂肪酸合成的影响。

对于ER + MCF-7细胞，α亚麻酸的IC 50值为17.55μM。吖啶橙/溴化乙锭和JC-1染色研究发现，α-亚麻酸处理后，早期和晚期凋亡信号以及线粒体去极化明显存在。α-亚麻酸使得细胞周期停滞在G2/M期。随后，研究人员探究了体内α亚麻酸对抗7, 12二甲基苯并蒽诱发癌变的效果。

组织病理学结构恢复和肿瘤微血管丧失等可说明α亚麻酸处理可明显影响细胞增殖。1 H NMR研究显示，α-亚麻酸可恢复正常的代谢。免疫印迹和qRT-PCR研究显示，α亚麻酸处理后，参与线粒体介导的死亡凋亡途径和缺氧微环境的抑制。

综上所述，该研究结果表明，α亚麻酸介导线粒体凋亡，抑制缺氧微环境，抑制脂肪酸的合成，具有抗癌作用。

原始出处：

Subhadeep Roy, Atul Kumar Rawat, et al., Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget. 2017 Sep 19; 8(41): 70049–70071. Published online 2017 Jul 25. doi: 10.18632/oncotarget.19551

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1795477, encodeId=b0171e954773a, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sun Aug 12 05:26:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255061, encodeId=2cb325506160, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Sun Oct 22 09:48:36 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254952, encodeId=aa7625495270, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Oct 21 23:32:40 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2018-08-12 仁医06

    #target#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1795477, encodeId=b0171e954773a, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sun Aug 12 05:26:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255061, encodeId=2cb325506160, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Sun Oct 22 09:48:36 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254952, encodeId=aa7625495270, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Oct 21 23:32:40 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-22 186****0580(小山羊）

    学习了谢谢了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1795477, encodeId=b0171e954773a, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sun Aug 12 05:26:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255061, encodeId=2cb325506160, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Sun Oct 22 09:48:36 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254952, encodeId=aa7625495270, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Oct 21 23:32:40 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 131****2916

    不错的文章值得推荐

    0

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