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J Gastroenterology: 腹部肥胖增加食道癌的风险

2020-01-18 不详 MedSci原创

据报道,通过体重指数(BMI)衡量的总体肥胖与食道鳞状细胞癌(ESCC)风险之间存在负相关关系。然而,以腰围(WC)衡量,ESCC(在韩国约占食管癌的90%)与腹部肥胖的关系可能不同。因此,本项研究旨在探究人群中腹部肥胖与食道癌之间的关系。

背景
据报道,通过体重指数(BMI)衡量的总体肥胖与食道鳞状细胞癌(ESCC)风险之间存在负相关关系。然而,以腰围(WC)衡量,ESCC(在韩国约占食管癌的90%)与腹部肥胖的关系可能不同。因此,本项研究旨在探究人群中腹部肥胖与食道癌之间的关系。

方法
本项研究为一项回顾性队列研究,研究人员对22809722名在2009年至2012年之间在韩国进行定期健康检查的人进行了研究(中位随访期为6.4年)。腹部肥胖的定义是男性WC> 90 cm,女性WC> 85 cm。研究使用危害比(HR),95%的置信区间(CI)χ 2检验和Cox比例风险模型调整混杂因素。主要观察结局是新发的食道癌。

结果
在调整了BMI之后,腹部肥胖增加了食道癌的风险(HR 1.29,95%CI 1.23-1.36)。WC以剂量依赖性方式增加食管癌的风险(p值<0.0001)。在超重(BMI 23–24.9 kg/m 2)和肥胖(BMI 25–29.9 kg/m 2)的个体中,腹部肥胖是食道癌的危险因素(HR 1.22,95%CI 1.11–1.34; HR 1.28, 95%CI分别为1.18–1.39)。

结论
腹部肥胖增加可能与食道癌风险增加有关。

原始出处:

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