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JCC: 克罗恩病小肠切除术后切缘微炎症对术后早期内镜复发的影响

2019-11-09 不详 MedSci原创

克罗恩病[CD]术后早期内镜复发的发病机制和危险因素尚不清楚。因此,本研究旨在验证回肠切除术后切除边缘的组织学炎症是否影响内镜复发。

背景和目标
克罗恩病[CD]术后早期内镜复发的发病机制和危险因素尚不清楚。因此,本研究旨在验证回肠切除术后切除边缘的组织学炎症是否影响内镜复发。

方法
研究人员对2012年1月至2018年1月在我院进行回盲肠切除术的CD患者进行了前瞻性随访。对标本在切除术边缘(回肠和结肠)的炎症进行了组织学分析。研究基于回肠盲肠切除术后6个月的结肠镜检查,评估了切缘的组织学结果是否与CD的内镜复发相关。其次,研究人员还评估了已知的危险因素和术前治疗对内镜CD复发的影响。

结果
本研究共纳入107位患者。回肠切除术后六个月,有23例[21.5%]出现内镜下CD复发。切除边缘的CD的组织学征象与较高的内镜下复发率相关[56.5% VS 4.8%,p <0.001]。内镜复发患者从诊断到手术的疾病持续时间[ p = 0.006]和肠切除长度[ p = 0.019]明显更长。吸烟也被证明是内镜复发的危险因素[ p = 0.028]。

结论
回肠盲肠切除术后,切除边缘的组织学炎症与术后早期内镜复发的较高风险显着相关。

原始出处:

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    2019-11-11 yjs木玉

    好好好好好好

    0

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