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Int J Cardiol:LDL-C和非HDL-C水平与缺血性卒中风险增加显著相关

2016-07-20 phylis 译 MedSci原创

背景:血脂水平与脑卒中发病率之间的相关性关系低于血脂水平和冠心病(CHD)的相关性。目的:评估总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和甘油三酯水平的地理、种族和民族差异是否与卒中事件的发生相关。方法:从卒中的地理和种族差异的原因研究(REGARDS)中,研究者评估基线无卒中的受试者的LDL-C,HCL-C,TC, non-HDL-C(total- HD

背景:血脂水平与脑卒中发病率之间的相关性关系低于血脂水平和冠心病(CHD)的相关性。

目的:评估总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和甘油三酯水平的地理、种族和民族差异是否与卒中事件的发生相关。

方法:从卒中的地理和种族差异的原因研究(REGARDS)中,研究者评估基线无卒中的受试者的LDL-C,HCL-C,TC, non-HDL-C(total- HDL-C)和甘油三酯的水平。应用Cox比例风险模型分析卒中事件和血脂的相关性。对于每个校正血脂(LDL-C、HDL-C、甘油三酯、TC、非HDL-C),研究者计算一系列的增量模型。

结果:分析队列为23867名受试者,平均随访时间事件为7.5±2.9年,1031例发生卒中(874例为缺血性和77例为出血性卒中)。高密度脂蛋白胆固醇基线水平与整体风险降低13%相关(HR 0.87,95% CI:0.81-0.93;出血性卒中为14%和缺血性卒中为16%),和TC与各种卒中风险下降 8%(HR 0.92,95% CI:0.87-0.99)相关。当结果充分校正后,LDL-C、non-HDL-C与缺血性卒中显著相关。当校正年级、种族、年龄*种族、性别、教育、地区或收入后,相关性没有显著差异。

结论:在正常人群中,基线LDL-C和非HDL-C水平与缺血性卒中风险增加显著相关。

原始出处:

Glasser SP, Mosher A, et al. What is the association of lipid levels and incident stroke? Int J Cardiol. 2016 Jun 23


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    2016-10-15 xugumin
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  4. 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  5. 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time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316414, encodeId=226713164144f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422538, encodeId=9cd81422538d3, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480818, encodeId=9e1714808180d, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

  6. 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time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316414, encodeId=226713164144f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422538, encodeId=9cd81422538d3, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480818, encodeId=9e1714808180d, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:23:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281222, encodeId=75581281222ee, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316414, encodeId=226713164144f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422538, encodeId=9cd81422538d3, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1819081, encodeId=560e1819081dd, content=<a href='/topic/show?id=8d08992182d' target=_blank style='color:#2F92EE;'>#非HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99218, encryptionId=8d08992182d, topicName=非HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat Oct 15 19:06:00 CST 2016, time=2016-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781716, encodeId=f8361e81716e4, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480818, encodeId=9e1714808180d, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-07-22 ZGMFX24A
  9. 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createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480818, encodeId=9e1714808180d, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Fri Jul 22 12:06:00 CST 2016, time=2016-07-22, status=1, ipAttribution=)]
    2016-07-22 zhwj
  10. 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