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Neuroimmune Pharmacology:肉桂有助于改善民众记忆力

2016-07-18 MedSci MedSci原创

研究人员对学习能力较差的小鼠饲喂肉桂之后发现,这些小鼠的学习记忆能力增强,该研究发表在Neuroimmune Pharmacology。神经内科教授Kalipada Pahan指出,这或许是一种安全简单且有效的提升学习记忆能力的好方法。桂皮又称肉桂、官桂或香桂,为樟科植物天竺桂、阴香、细叶香桂、肉桂或川桂等树皮的通称。本品为常用中药,又为食品香料或烹饪调料。商品桂皮的原植物比较复杂,约有十余种,均

研究人员对学习能力较差的小鼠饲喂肉桂之后发现,这些小鼠的学习记忆能力增强,该研究发表在Neuroimmune Pharmacology。神经内科教授Kalipada Pahan指出,这或许是一种安全简单且有效的提升学习记忆能力的好方法。


桂皮又称肉桂、官桂或香桂,为樟科植物天竺桂、阴香、细叶香桂、肉桂或川桂等树皮的通称。本品为常用中药,又为食品香料或烹饪调料。商品桂皮的原植物比较复杂,约有十余种,均为樟科樟属植物。

很少人知道为什么有些人天生善于学习,为什么有些人努力奋斗仍然不得要领,也不能从失败中吸取足够的经验教训。Pahan认为,通过找出导致民众学习记忆能力差异的大脑作用机制有助于改善民众的记忆和学习功能。 

研究人员对学习记忆能力较差的小桂有助于改善调整这些蛋白质并改善小鼠的学习和记忆能力。
鼠的大脑海马区蛋白质进行了探究。研究人员发现,这些小鼠海马区的蛋白质含量较少。

相比学习能力更强的小鼠而言,学习能力较差的小鼠大脑海马区的GABAA受体alpha5亚基或或GABRA5蛋白质含量更多。对小鼠饲喂肉在食用肉桂之后,小鼠将其代谢为苯甲酸钠,可以用作治疗脑损伤。 

苯甲酸钠可增加小鼠大脑中CREB的含量并降低GABRA5含量,因此有助于改善小鼠的学习和记忆功能。

研究人员让实验小鼠在一个有20个洞的迷宫中,为期2天教导和培训帮助他们寻找到正确的洞口,同时观察小鼠是否能在经过培训后自己找到正确洞口。研究人员发现,通过使用肉桂,他们成功地提高了学习记忆能力较差小鼠的记忆功能。饲喂肉桂1个月后,学习能力较差的小鼠的记忆功能明显得以提高,学习能力较强的小鼠学习记忆能力不变。

民众之间学习和记忆能力的差距是全球性问题,研究人员表示仍需进行更进一步的研究,以探究其是否可以成功应用于人类。

Pahan教授和同事既往发现食用肉桂可改善帕金森病小鼠的病变大脑。但是并不是所有的肉桂都可改善民众的大脑功能,研究人员指出,美国和中国的肉桂、锡兰肉桂效果较好。

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    2016-10-11 ylzr123

    好文,值得推荐。

    0

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    2017-06-17 智智灵药
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    2016-09-16 飞天熊

    没有多大临床意义

    0

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    2016-12-16 jj000001
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    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

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    2016-07-20 quxin068

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