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JAHA:伴侣逝世与缺血性卒中和脑出血风险的关系

2020-11-17 MedSci原创 MedSci原创

IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

据报道,压力会触发卒中,而伴侣逝世可能是一种极度应激事件。然而,先前的研究在丧亲是否与卒中风险有关方面得出了相互矛盾的结果,这可能是由于缺血性卒中(IS)和脑出血(ICH)之间的区分不足所致。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用全国范围内的高质量注册资源,分别探究了丧亲与IS和ICH之间的关联。

该研究队列纳入了伴侣在2002年至2016年期间死亡的所有丹麦人,并以1:2比例在性别、年龄和日历时间上匹配一组同居人作为对照组。研究人员使用Cox比例风险回归估计长达5年的随访期间调整后的风险比(aHRs)和相应的95%CI。

在研究期间,有278758个人经历了伴侣逝世,其中7684人在随后的5年内发生IS(与未丧亲者相比aHR为1.11;95%CI为1.08-1.14),1139人发生ICH(aHR为1.13;95%CI为1.04–1.23)。对于ICH,估计的关联在伴侣逝世后最初30天内趋于增强(aHR为1.66;95%CI为1.06-2.61),尤其是女性(aHR为1.99;95%CI为1.06-3.75)。从绝对数字上来说,伴侣逝世者在30天时IS的累积发生率为0.73人/1000,对照组为0.63人/1000,而ICH的相应为0.13人/1000和0.08人/1000。

由此可见,IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

原始出处:

Morten Fenger‐Grøn.et al.Death of a Partner and Risks of Ischemic Stroke and Intracerebral Hemorrhage: A Nationwide Danish Matched Cohort Study.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/10.1161/JAHA.120.018143

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    2020-11-19 咻凡

    IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

    0

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    2020-11-19 zhaohui6731
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    2020-11-18 ms8000001032906359

    学习了

    0

  8. 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    2020-11-18 咻凡

    IS和ICH风险的与伴侣逝世存在统计学显著正相关,特别是在短期内。但是,绝对风险差异很小。

    0

  9. 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    2020-11-18 一洼菜地

    学习了

    0

  10. 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    2020-11-18 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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TST试验显示,在2860例伴有脑血管粥样硬化性狭窄的缺血性卒中患者中,将低密度脂蛋白胆固醇浓度控制在70 mg/dL以下可降低主要心血管事件风险。但该策略对颈动脉粥样硬化演变的影响尚不明确

Stroke:高血糖与缺血性卒中患者血管内治疗后不良结局相关

入院血糖升高与功能不良和血管内治疗后症状性颅内出血风险增加有关。

Stroke:胃肠道疾病与首次缺血性卒中风险之间的关系

在调整了人口统计学特征和已知的卒中危险因素后,有些胃肠道疾病与未来缺血性卒中的风险增加相关。

J INTERN MED:痴呆患者服用钙通道阻滞剂与生存率和缺血性卒中之间的关系

对于AD和DLB-PDD的痴呆患者服用氨氯地平可降低死亡风险。与其他CCB使用者相比,使用氨氯地平的AD患者发生缺血性卒中的风险较低。

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