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Heart:瑞典地区23年间心肌梗死后的生存性别差异调查!

2017-08-09 MedSci MedSci原创

近期,一项发表在杂志Heart上的全国性研究中,研究者们调查了急性心肌梗死(AMI)后生存性别差异的年龄特异性和性别特征趋势,此项研究的受试人群包括了在医院外发生的冠心病(CHD)死亡。此项研究在瑞典进行,为观察性研究,研究对象为1987-2010年间年龄在35-84岁的658110名首次发生CHD事件的患者(35.7%的女性)。此项研究结果显示:年龄调整的28天病例死亡率由23.5%下降至8.5

近期,一项发表在杂志Heart上的全国性研究中,研究者们调查了急性心肌梗死(AMI)后生存性别差异的年龄特异性和性别特征趋势,此项研究的受试人群包括了在医院外发生的冠心病(CHD)死亡。


此项研究在瑞典进行,为观察性研究,研究对象为1987-2010年间年龄在35-84岁的658110名首次发生CHD事件的患者(35.7%的女性)。

此项研究结果显示:年龄调整的28天病例死亡率由23.5%下降至8.5%(p <0.05)。在住院病例中,与同龄男性相比,年龄在35-54岁之间的女性的短期生存率较差;35-54岁女性相对于男性的HR为1.63(95%CI为1.28〜2.08),55-64岁为1.28(95%CI为1.12〜1.46)(2005年至2010年);但在调整合并症后,男女之间的差异不再显着(HR 1.25(95%CI 为0.97〜1.61)和1.05(95%CI 为0.91〜1.20))。

当包括医院外的CHD死亡病人时,无论年龄和时间段,女性的预后都较好。在前28天存活的患者中,男性和女性的年龄调整后的1年死亡率均从15.3%下降到7.7%(p <0.05)。调整合并症后,75岁以下患者的性别差异无显着性差异。75-84岁女性的28天幸存者与老年男性相比预后更好。

此项研究结果表明:调整合并症后,年龄小于55岁的住院女性AMI患者短期较差的结果并未持续。当包括医院外的CHD死亡病人时,女性的短期预后一直较好。当合并症的差异被考虑时,在28天的幸存者中,女性患者并不比男性更差。

原始出处:
Berg J, Björck L, et al. Sex differences in survival after myocardial infarction in Sweden, 1987-2010. Heart. 2017 Aug 7. pii: heartjnl-2016-310281. doi: 10.1136/heartjnl-2016-310281. 

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    2017-08-11 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=1356462, encodeId=2e80135646218, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 11 08:48:00 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562657, encodeId=9908156265e0a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Aug 11 08:48:00 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231952, encodeId=baec231952ad, content=学习了,感谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Aug 09 20:45:46 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231878, encodeId=7c9c2318e85f, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Aug 09 18:10:19 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-11 slcumt
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    2017-08-09 1e0f8808m18(暂无匿称)

    学习了,感谢分享。

    0

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    2017-08-09 楠博One

    学习谢谢分享

    0

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