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香港中文大学率先成功破解鼻咽癌全基因组图谱

2017-03-08 佚名 中国新闻网

香港中文大学(中大)7日公布,其医学院研究人员率先成功破解鼻咽癌全基因组图谱,这是在全球已公布的研究中,首个有系统地进行鼻咽癌全基因组测序分析的研究。

香港中文大学(中大)7日公布,其医学院研究人员率先成功破解鼻咽癌全基因组图谱,这是在全球已公布的研究中,首个有系统地进行鼻咽癌全基因组测序分析的研究。

研究人员指出,鼻咽癌患者大多涉及感染EB病毒(Epstein-BarrVirus),中大医学院于2015至16年间分析了超过100名感染EB病毒的鼻咽癌患者肿瘤样本。


中大医学院病理解剖及细胞学系教授罗国炜表示,是次研究发现了更多基因变异及结构变异的数据,这或许能解释为何免疫治疗或标靶治疗在不同病人身上,会有相异的临床反应;同时也有助于医生评估病人接受特定治疗的预后情况。

研究还发现多种助长鼻咽癌肿瘤生长的新基因特质,例如负责调节细胞发炎机制“NF-κB通道”的蛋白若出现基因突变,便会使得细胞扩散、复制及增长,进而会引发癌症。新基因特质的发现将有助于发展个人化治疗,从而帮助患者选择合适自己的治疗方式。

数据显示,每年香港的鼻咽癌新症达800宗。由于缺乏早期病征,60%至70%患者在确诊时已经是晚期。2014年香港癌症资料统计中心的数据指出,834名鼻咽癌患者中,约44%达第三期,29.5%为第四期。

56岁的徐先生是其中一位鼻咽癌患者,也参与了是次研究。最初他因为视力减弱并出现重影,去医院检查后才发现得了鼻咽癌。他说:“当时连走路都看不清,上街都要老婆牵着。”

徐先生表示,当得知这一研究治疗时,“仿佛看到了希望”。他说:“我想献出自己的一份力。如果没有人愿意参与研究,那这个病就永远不会有下一步的进展,停留在原地,永远都治不好。”徐先生觉得参与这次研究很值得。

经过近10年的治疗后,他的活动能力已基本恢复,并在2010至2017年,每年坚持跑一次全程马拉松。

罗国炜透露,学院正跟英国的大学研发针对“NF-κB通道”的相关抑制性药物,相信会为病人治疗带来新希望。

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    2017-05-31 风的凉快

    现在这种药研发出来了嘛?

    0

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    2017-03-15 喜婷

    学习了

    0

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    2017-03-08 tofsw

    人类的读音啊

    0

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