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Stroke:白质高信号介导的皮质变化可致认知减退

2015-02-05 高晓方 译 医学论坛网

荷兰一项研究表明,由白质高信号(WMH)介导的皮质变化和可能导致认知减退。论文1月8日在线发表于《卒中》(Stroke)。 此项研究共纳入426例年龄为50~85岁的脑小血管病患者。受试者无痴呆,并均接受MRI检查。实施皮质厚度分析,并手工分段评估WMH。评估WMH、皮质厚度和认知的相关性。 结果显示,在额颞区域中WMH高负荷与皮质厚度较小具有相关性,在旁中央区域其则与皮质厚度较大

荷兰一项研究表明,由白质高信号(WMH)介导的皮质变化和可能导致认知减退。论文1月8日在线发表于《卒中》(Stroke)。

此项研究共纳入426例年龄为50~85岁的脑小血管病患者。受试者无痴呆,并均接受MRI检查。实施皮质厚度分析,并手工分段评估WMH。评估WMH、皮质厚度和认知的相关性。

结果显示,在额颞区域中WMH高负荷与皮质厚度较小具有相关性,在旁中央区域其则与皮质厚度较大具有相关性。网络破坏指标与WMH和认知表现具有相关性。此外,特定白质束的WMH与区域特异性皮质厚度和网络指标具有相关性。认知表现与额颞区域皮质厚度和网络指标具有相关性,与WMH则无关。

原始出处:

Tuladhar AM1, Reid AT1, Shumskaya E1, de Laat KF1, van Norden AG1, van Dijk EJ1, Norris DG1, de Leeuw FE2.Relationship between white matter hyperintensities, cortical thickness, and cognition.Stroke. 2015 Feb;46(2):425-32. doi: 10.1161/STROKEAHA.114.007146. Epub 2015 Jan 8.


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    2015-03-18 xiaoai5777

    好文章,的确

    0

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    2015-02-16 windmilL1989

    已阅

    0

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