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Neuroradiology:后交通动脉瘤栓塞术后动眼神经麻痹能够恢复吗?多久才能恢复?

2017-12-21 杨中华 脑血管病及重症文献导读

单侧动眼神经麻痹(oculomotor nerve palsy,ONP)是后交通动脉瘤的常见症状,每5个后交通动脉瘤就有一例ONP,50% ONP与蛛网膜下腔出血有关。合并ONP后交通动脉瘤的治疗策略包括纤维外科夹闭和血管内弹簧圈治疗。预防动脉瘤破裂能够促进ONP症状(完全或不完全)的恢复,比如同侧上睑下垂、眼肌麻痹、复视和瞳孔散大。


单侧动眼神经麻痹(oculomotor nerve palsy,ONP)是后交通动脉瘤的常见症状,每5个后交通动脉瘤就有一例ONP,50% ONP与蛛网膜下腔出血有关。合并ONP后交通动脉瘤的治疗策略包括纤维外科夹闭和血管内弹簧圈治疗。预防动脉瘤破裂能够促进ONP症状(完全或不完全)的恢复,比如同侧上睑下垂、眼肌麻痹、复视和瞳孔散大。

大部分研究认为,后交通动脉瘤的搏动性刺激是ONP的主要原因。其他原因还包括动脉瘤对动眼神经直接压迫,以及动脉瘤SAH的刺激。纤维外科夹闭后交通动脉瘤,能够解除搏动和压迫,因此对ONP有治疗作用。动脉瘤血管内弹簧圈栓塞术也能促进动眼神经功能恢复,其机制可能与消除了动脉瘤搏动有关。不过,合理的治疗方式仍然存在争论。

动脉瘤血管内弹簧圈栓塞术后影响ONP恢复的研究都是临床病例报道,具有局限性。并且往往忽视了动脉瘤破裂出血的影响。

2017年11月来自南京医科大学第一附院的Qing-Quan Zu等在Neuroradiology上发表了他们的回顾性研究结果,目的在于评价破裂后交通动脉瘤经过血管内治疗后ONP的预后,探讨ONP恢复的预测因素。

从2010年5月到2015年10月共纳入了210例血管内治疗的后交通动脉瘤。其中34例为破裂动脉瘤合并完全或不全ONP。他们发现ONP完全缓解21例(61.8%),不全缓解8例(23.5%)。栓塞术后平均缓解时间为24.5天。5例患者没有任何恢复。最初不全ONP者没有一例发生恶化。最初不全ONP者更容易完全恢复(OR = 4.17; 95% CI, 0.75–23.18; P = 0.103)。

最终作者认为血管内治疗能够有效改善ONP,最初不全ONP者更容易完全恢复。

原始出处:

Zu QQ1, Liu XL1, Wang B,et al.Recovery of oculomotor nerve palsy after endovascular treatment of ruptured posterior communicating artery aneurysm.Neuroradiology. 2017 Nov;59(11):1165-1170. doi: 10.1007/s00234-017-1909-9. Epub 2017 Sep 6.

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    2017-12-23 yuandd
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    2017-12-21 圣艮山

    学习了很多事情

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