J Dent Res：头颈癌中关于Wnt/β-catenin信号的新启示

2018-05-20 lishiting MedSci原创

头颈癌的发生最初以头颈鳞状细胞癌(HNSCC)的方式出现，它是一种使机体衰弱的恶性肿瘤，具有高发病率、低存活率以及治疗选择有限的特点。众多证据表明，Wnt/β-catenin信号通路对于HNSCC的病理生物机制具有重要作用。Wnt/β-catenin信号影响多种细胞进程，它可以促使癌细胞维持和扩展其未成熟的干细胞样表型、增殖、延展存活，并按照间充质的方式具备侵袭特性。β-catenin为经典Wnt

头颈癌的发生最初以头颈鳞状细胞癌(HNSCC)的方式出现，它是一种使机体衰弱的恶性肿瘤，具有高发病率、低存活率以及治疗选择有限的特点。众多证据表明，Wnt/β-catenin信号通路对于HNSCC的病理生物机制具有重要作用。Wnt/β-catenin信号影响多种细胞进程，它可以促使癌细胞维持和扩展其未成熟的干细胞样表型、增殖、延展存活，并按照间充质的方式具备侵袭特性。β-catenin为经典Wnt信号的中间体，它即是一个E-粘连蛋白结点的结构组成以平衡其功能，也是多种靶基因的转录辅助激活子。近期对头颈癌基因组鉴定的结果显示，当β-catenin在HNSCC中不频繁发生突变时，其活性不会被β-catenin， NOTCH1， FAT1和AJUBA的基因编码上游调节因子所抑制。β-catenin通过与不同转录因子和转录辅助激活子及辅助抑制子的相互作用，Wnt/β-catenin信号可以广泛影响后生及转录活性。另外，Wnt/β-catenin在众多信号网络及代谢途径中的功能也可以调节其自身的活性。除了对肿瘤上皮细胞的作用，β-catenin的活性也通过调节细胞外基质的重建、纤维变性过程和免疫

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2018-05-29 131****1460

学习了受益匪浅

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2018-05-22 DEXTER3139

#头颈癌#

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2018-05-22 zhwj

#WNT#

59 0
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2018-05-21 131****1460

学习了受益匪浅

99 0
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2018-05-21 kafei

学习了谢谢

80 0
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2018-05-20 有备才能无患

头颈癌的发生最初以头颈鳞状细胞癌(HNSCC)的方式出现.它是一种使机体衰弱的恶性肿瘤.具有高发病率.低存活率以及治疗选择有限的特点.众多证据表明.Wnt/β-catenin信号通路对于HNSCC的病理生物机制具有重要作用

70 0
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2018-05-20 清风拂面

谢谢分享学习

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