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JAMA Neurol：早期脑结构改变与阿尔茨海默病遗传易感性相关

2013-11-28 高晓方 译 医学论坛网

早期脑结构改变阿尔茨海默病遗传易感性
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美国一项研究表明，早期脑结构改变与阿尔茨海默病遗传易感性相关，并有可能成为阿尔茨海默病预防治疗的靶位。论文11月25日在线发表于《美国医学会杂志·神经病学》（JAMA Neurol）。 此项研究共纳入162例典型发育的2～25个月婴儿，并在睡眠时实施了脑MRI检查。受试婴儿均无阿尔茨海默病以及其它神经或精神疾病家族史。在载脂蛋白E（APOE）ε4携带者和非携带者中对白质髓鞘水部

美国一项研究表明，早期脑结构改变与阿尔茨海默病遗传易感性相关，并有可能成为阿尔茨海默病预防治疗的靶位。论文11月25日在线发表于《美国医学会杂志·神经病学》（JAMA Neurol）。

此项研究共纳入162例典型发育的2～25个月婴儿，并在睡眠时实施了脑MRI检查。受试婴儿均无阿尔茨海默病以及其它神经或精神疾病家族史。在载脂蛋白E（APOE）ε4携带者和非携带者中对白质髓鞘水部分（MWF）和灰质容积（GMV）进行比较。ε4携带和非携带者在年龄、妊娠期、出生体重和孕母年龄等方面相互匹配。

结果显示，在易受阿尔茨海默病累及的楔前叶、后/中扣带、侧颞叶和中枕颞区中，ε4携带者的MWF和GWM低于非携带者。在广泛前额区中，ε4携带者的MWF和GWM高于非携带者。在2～6个月婴儿中上述结果亦具有统计学意义。在ε4携带者的后白质区中，MWF与年龄的相关性出现减弱。

原文出处：

Douglas C. Dean III; Beth A. Jerskey; Kewei Chen; Hillary Protas; Pradeep Thiyyagura; Auttawat Roontiva; Jonathan O'Muircheartaigh; Holly Dirks; Nicole Waskiewicz; Katie Lehman; Ashley L. Siniard; Mari N. Turk; Xue Hua; Sarah K. Madsen; Paul M. Thompson; Adam S. Fleisher; Matthew J. Huentelman; Sean C. L. Deoni; Eric M. Reiman.Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease A Cross-sectional Imaging Study.JAMA Neurol. Published online November 25, 2013. doi:10.1001/jamaneurol.2013.4544


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    2014-03-17 ms1948154235210413

    #阿尔茨#

    0

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    2014-03-23 12498da4m32(暂无昵称)

    #阿尔茨海#

    0

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    2014-06-08 yinhl1978

    #Neurol#

    0

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    2013-11-30 kcb071

    #遗传易感性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1816597, encodeId=3d4d181659e52, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Mar 17 10:54:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817620, encodeId=576d181e62032, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Mar 23 20:54:00 CST 2014, time=2014-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999354, encodeId=be87199935403, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jun 08 10:54:00 CST 2014, time=2014-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454696, encodeId=02221454696a1, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460505, encodeId=279c1460505c7, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469974, encodeId=721814699e422, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556478, encodeId=c5a715564e82f, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=)]
    2013-11-30 FukaiBao

    #易感性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1816597, encodeId=3d4d181659e52, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Mar 17 10:54:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817620, encodeId=576d181e62032, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Mar 23 20:54:00 CST 2014, time=2014-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999354, encodeId=be87199935403, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jun 08 10:54:00 CST 2014, time=2014-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454696, encodeId=02221454696a1, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460505, encodeId=279c1460505c7, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469974, encodeId=721814699e422, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556478, encodeId=c5a715564e82f, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=)]
    2013-11-30 yhj-time

    #阿尔茨海默#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1816597, encodeId=3d4d181659e52, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Mon Mar 17 10:54:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817620, encodeId=576d181e62032, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Mar 23 20:54:00 CST 2014, time=2014-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999354, encodeId=be87199935403, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jun 08 10:54:00 CST 2014, time=2014-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454696, encodeId=02221454696a1, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460505, encodeId=279c1460505c7, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469974, encodeId=721814699e422, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556478, encodeId=c5a715564e82f, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sat Nov 30 01:54:00 CST 2013, time=2013-11-30, status=1, ipAttribution=)]
    2013-11-30 wmr116

    #脑结构#

    0

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