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Prostate Cancer P D:健康和前列腺癌不同阶段男性的身体成分、身体功能和生活质量

2021-02-09 AlexYang MedSci原创

最近,有研究人员比较了PC和非癌症对照组(CON)各进展阶段组患者的身体成分、身体功能和QoL情况。

最近,有研究人员比较了PC和非癌症对照组(CON)各进展阶段组患者的身体成分、身体功能和QoL情况

研究人员在对激素敏感的PC(HSPC,n=43)或转移性去势抵抗性PC(mCRPC,n=22)或CON(n=37)的男性中,测定了相对和绝对瘦肉和脂肪质量、身体功能(6米步行、椅子站立、定时起身走[TUG]以及爬楼梯)和QoL。结果表明,相对的身体成分在所有分组中存在差异。mCRPC与CON的绝对脂肪质量相比少了39%。与CON和HSPC相比,mCRPC的TUG和椅子站立分别慢了约71%和约33%,而mCRPC与CON相比,爬楼梯慢了约29%,6米步行慢了约18%。相对身体成分与身体功能相关(r=0.259-0.385)。虽然身体成分和身体功能不影响QoL,但mCRPC的总体QoL和几个子量表与CON存在临床相关差异。

身体组成、身体功能和生活质量之间的相关性

最后,研究人员指出,PC进展与身体成分和身体功能的恶化有关。由于组间ADT长度相似,mCRPC的ARSI使用可能部分促成了这些变化。鉴于ADT期间改善瘦肉质量的困难,减少脂肪的干预措施可能会减轻激素治疗的副作用。

原始出处:

Erik D Hanson, Cameron K Stopforth, Mohamdod Alzer et al. Body composition, physical function and quality of life in healthy men and across different stages of prostate cancer. Prostate Cancer P D. Jan 2021

 

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    2021-02-11 lsndxfj
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    2021-02-11 sunylz
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    2021-02-09 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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