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Am J Resp Crit Care:减肥对阻塞性睡眠呼吸暂停严重程度的影响

2020-08-17 MedSci原创 MedSci原创

接受ILI减肥的OSA和2型糖尿病参与者在治疗10年时降低了OSA严重程度。ILI和DSE组在10年时OSA严重程度无差异。

减肥被推荐用于阻塞性睡眠呼吸暂停(OSA)治疗。近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,该研究旨在明确通过强化生活方式干预(ILI)减肥对减轻OSA严重程度是否具有益处,并且能否维持10年。

研究人员对超重/肥胖、2型糖尿病和OSA睡眠AHEAD研究纳入的264名成年人中的134位成年人进行10年多导睡眠图随访,他们随机分配至ILI进行减肥或糖尿病支持和教育(DSE)。研究人员主要监测了呼吸暂停低通气指数(AHI)的变化。

ILI参与者在1年、2年、4年和10年时的平均体重减轻分别为10.7±0.7(SE)、7.4±0.7、5.1±0.7和7.1±0.8 kg,相比于DSE组在1年、2年和4年时体重减轻要多1kg,在10年时体重减轻要多出3.5±0.8 kg(P≤0.0001)。在1年、2年和4年时,ILI的AHI分别比DSE要少9.7次、8.0次、7.9次事件/小时(P≤0.0004)和在10年时要少4.0次事件/小时(P=0.109)。AHI随时间的变化与体重减轻程度、基线AHI、随访年份(P<0.0001)以及与体重变化无关的干预措施(P=0.01)有关。ILI(34.4%)比DSE(22.2%)在10年时获得OSA缓解更为常见。

由此可见,接受ILI减肥的OSA和2型糖尿病参与者在治疗10年时降低了OSA严重程度。ILI和DSE组在10年时OSA严重程度无差异。采用ILI在10年内OSA严重程度的改善与体重、基线AHI的变化以及与体重变化无关的干预措施存在相关性。

原始出处:

Samuel T Kuna.et al.Effects of Weight Loss on Obstructive Sleep Apnea Severity: 10-year Results of the Sleep AHEAD Study.AM J RESP CRIT CARE.2020.https://www.atsjournals.org/doi/abs/10.1164/rccm.201912-2511OC

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createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2021-08-26 一米阳光☀️

    👍

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    2020-12-13 tomyang96
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GetPortalCommentsPageByObjectIdResponse(id=809903, encodeId=358980990314, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Mon Aug 17 21:32:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809792, encodeId=9626809e92d2, content=<a href='/topic/show?id=8bad9e662a4' target=_blank style='color:#2F92EE;'>#阻塞性睡眠呼吸暂停#</a>减肥后, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97662, encryptionId=8bad9e662a4, topicName=阻塞性睡眠呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

    👍🏻

    0

  5. 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time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810862, encodeId=f6768108622b, content=!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:07 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810861, encodeId=fcda810861c4, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:05 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596602, encodeId=1a40159660214, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Aug 19 07:01:13 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809978, encodeId=db078099e850, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=ms4000001242976819, createdTime=Tue Aug 18 08:13:31 CST 2020, time=2020-08-18, status=1, ipAttribution=), 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createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

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  6. 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time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810862, encodeId=f6768108622b, content=!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:07 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810861, encodeId=fcda810861c4, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:05 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596602, encodeId=1a40159660214, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Aug 19 07:01:13 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809978, encodeId=db078099e850, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=ms4000001242976819, createdTime=Tue Aug 18 08:13:31 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809903, encodeId=358980990314, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Mon Aug 17 21:32:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809792, encodeId=9626809e92d2, content=<a href='/topic/show?id=8bad9e662a4' target=_blank style='color:#2F92EE;'>#阻塞性睡眠呼吸暂停#</a>减肥后, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97662, encryptionId=8bad9e662a4, topicName=阻塞性睡眠呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-08-19 ms5000000741733160

    👍

    0

  7. 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time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810862, encodeId=f6768108622b, content=!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:07 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810861, encodeId=fcda810861c4, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:05 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596602, encodeId=1a40159660214, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Wed Aug 19 07:01:13 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809978, encodeId=db078099e850, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=ms4000001242976819, createdTime=Tue Aug 18 08:13:31 CST 2020, time=2020-08-18, status=1, ipAttribution=), 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createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
  8. 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time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810862, encodeId=f6768108622b, content=!, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:07 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810861, encodeId=fcda810861c4, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:58:05 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596602, encodeId=1a40159660214, content=<a 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GetPortalCommentsPageByObjectIdResponse(id=809903, encodeId=358980990314, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Mon Aug 17 21:32:34 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809792, encodeId=9626809e92d2, content=<a href='/topic/show?id=8bad9e662a4' target=_blank style='color:#2F92EE;'>#阻塞性睡眠呼吸暂停#</a>减肥后, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97662, encryptionId=8bad9e662a4, topicName=阻塞性睡眠呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-08-18 ms4000001242976819

    学习了

    0

  9. 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createdTime=Mon Aug 17 19:30:49 CST 2020, time=2020-08-17, status=1, ipAttribution=)]
    2020-08-17 1238d654m87暂无昵称

    学习

    0

  10. 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