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elife:人类大脑中发现有淋巴管

2017-10-04 海北 MedSci原创

大脑如何清理垃圾?身体的其他器官通过淋巴系统实现该功能。淋巴管网络用和血管类似的方式延伸,穿过身体。来自细胞,细菌,病毒的垃圾和过量液体从身体的组织排出到淋巴管中,淋巴管再将其转移到血液中。而后,身体的垃圾被血管带到肾脏,将其过滤并排出。

大脑如何清理垃圾?身体的其他器官通过淋巴系统实现该功能。淋巴管网络用和血管类似的方式延伸,穿过身体。来自细胞,细菌,病毒的垃圾和过量液体从身体的组织排出到淋巴管中,淋巴管再将其转移到血液中。而后,身体的垃圾被血管带到肾脏,将其过滤并排出。淋巴管也是白细胞循环的高速公路,有助于对抗感染,是免疫系统的重要组成部分。与其他器官不同,传统意义上我们认为大脑不含淋巴管,那么它是如何排出垃圾的呢?

来自美国国立卫生研究院的研究人员报告,在人类和非人类灵长类动物(普通狨猴)中存在脑膜淋巴管。其利用高分辨率,非侵入性临床MRI成像在体内观察定位脑淋巴管。在T2-FLAIRT1加权黑血成像时,钆布醇能够增强淋巴管成像。钆布醇是一种钆基造影剂,具有高渗透性,能够穿过毛细血管内皮屏障外渗,但钆膦维司不能,其被用作血池造影剂。这些脉管的形态,与硬脑膜静脉窦一起,和啮齿动物的脑膜淋巴系统相似。在灵长类动物中,通过免疫组织化学手段,研究人员发现脑膜淋巴管显示典型的淋巴管内皮标志物。

因此,这一发现有助于更好地了解中枢神经系统淋巴引流的正常生理学和神经系统疾病的潜在畸变。


原始出处:

Martina Absinta et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRIeLife, 2017; 6 DOI: 10.7554/eLife.29738


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    2018-05-20 clmlylxy
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    2018-04-23 膀胱癌
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    2017-10-13 杨利洪

    学习了提高了

    0

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    2017-10-07 186****0580(小山羊)

    学习了谢谢了

    0

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    2017-10-05 amyloid
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    2017-10-04 lyh994

    大脑炎症就有望突破了

    0

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    2017-10-04 刘煜

    谢谢发现.学习了

    0

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    2017-10-04 衣带渐宽

    学习

    0

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