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GUT:口服抗凝血药或非甾体抗炎药不会影响结肠癌粪便免疫化学检测的准确性

2018-06-06 zhangfan MedSci原创

研究发现,口服抗凝血药或非甾体抗炎药不会影响结肠癌粪便免疫化学检测的准确性,筛查前无需停药

目前,大多数结直肠癌筛查人群优先选择粪便免疫化学检测(FIT),而老年人群中接受口服抗凝血药(OACS)或非甾体抗炎药(NSAID)进行心血管事件预防的比例较高,可能会刺激结肠良性和癌前病变出血,导致FIT结果假阳性。近日研究人员就OACs和NSAIDs治疗对FIT检测的影响进行了考察。

本次研究为系统综述和荟萃分析研究,收集截止2017年6月的相关研究资料,比较OACs 和/或NSAIDs使用人群以及非使用人群接受FIT结肠癌筛查结果的研究纳入本次分析。研究的主要终点是因OACs/NSAIDs治疗导致的FIT晚期肿瘤阳性预测(PPVAN)。

8个研究,2022个筛查记录纳入本次分析,总计3563名患者FIT筛查结果阳性。服用OACs人群的PPVAN率为37.6%,而非服药人群为40.3%。阿司匹林以及其他NSAID人群累积PPVAN率为38.2%,而非服药人群为39.4%。

研究发现,口服抗凝血药或非甾体抗炎药不会影响结肠癌粪便免疫化学检测的准确性,筛查前无需停药。

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    2018-06-08 Homburg
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    2018-06-06 蔬菜

    有学习了最新研究成果.谢谢谢谢分享!

    0

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    2018-06-06 flysky120

    学习一下知识了谢谢

    0

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