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ONF:耐冲击运动对进行ADT治疗的前列腺癌患者有何好处?

2015-07-03 MedSci MedSci原创

目的:对于使用对雄激素剥夺疗法(ADT)治疗的前列腺癌患者而言,运动治疗是否能降低反映癌症进展的生物标志物(PCSS)?方式:该研究为随机对照研究。地点位于俄勒冈市卫生与科学大学护理学院,参与人员为51位患有前列腺癌的患者。他们被随机分配到实验组和对照组,其中实验组患者进行为期一年的耐冲击运动。我们研究了患者机体发生的改变及机体组成部分的改变和癌症相关的生物标志物含量的变化、年龄和机体脂肪含量改变

目的:
对于使用对雄激素剥夺疗法(ADT)治疗的前列腺癌患者而言,运动治疗是否能降低反映癌症进展的生物标志物(PCSS)?

方式:
该研究为随机对照研究。地点位于俄勒冈市卫生与科学大学护理学院,参与人员为51位患有前列腺癌的患者。他们被随机分配到实验组和对照组,其中实验组患者进行为期一年的耐冲击运动。
我们研究了患者机体发生的改变及机体组成部分的改变和癌症相关的生物标志物含量的变化、年龄和机体脂肪含量改变对生物标记物变化的影响。

主要研究变量:
我们观察的主要指标是:患者机体物质的组成(总脂肪含量、躯干脂肪含量和瘦体重)、胰岛素、胰岛素样生长因子1和性激素结合球蛋白等物质的分泌。

结果:
对36位前列腺癌患者,我们在实验前对他们进行基础测量获取相关数据,在12月后再次测试并获取数据。结果表明,实验组相比对照组而言,他们的总脂肪含量(p = 0.02)和躯干脂肪含量(p = 0.06)减少 ;总脂肪含量和躯干脂肪含量的减少间接影响两组参与人员一年内胰岛素含量的变化(p < 0.05);随着年龄的增长,胰岛素对机体运动的反应能力降低,且减少的含量逐年减少(p = 0.03)。

结论:
研究表明,耐冲击运动会降低使用雄激素剥夺疗法(ADT)的前列腺癌患者的躯体脂肪含量,反而能起到减少胰岛素分泌的作用。

对护理的启迪:
对于前列腺癌患者,护士应指导他们进行运动,以减少发生肥胖的危险,并预防包括癌症进展转移在内的各种相关并发症。同时积极进行各种心理健康教育,以提高患者的心理素质。

原始出处:
Kerri M. Winters-StoneNathan DieckmannGianni F. Maddalozzo
Jill A. BennettChristopher W. RyanTomasz M. Beer.Resistance Exercise Reduces Body Fat and Insulin During Androgen-Deprivation Therapy for Prostate Cancer. ONF 2015, 42(4), 348-356 DOI: 10.1188/15.ONF.348-356 

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    2015-08-06 hlycom3356

    期待有更多研究

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=35149, encodeId=6c3e3514930, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:22:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30836, encodeId=f98830836c4, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30837, encodeId=601f3083e98, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30838, encodeId=03c2308381f, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30839, encodeId=989d308399f, content=(^_^), beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477958, encodeId=d3eb14e795820, content=<a href='/topic/show?id=dd832018bd' target=_blank style='color:#2F92EE;'>#ADT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2018, encryptionId=dd832018bd, topicName=ADT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87be7387847, createdName=124984e7m85暂无昵称, createdTime=Sun Jul 05 12:31:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30700, encodeId=e9fe30e00f4, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 21:56:00 CST 2015, time=2015-07-04, status=1, ipAttribution=)]
    2015-07-05 18619c0a62m

    看看

    0

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    2015-07-05 18619c0a62m

    (⊙o⊙)

    0

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    2015-07-05 18619c0a62m

    呵呵

    0

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    2015-07-05 18619c0a62m

    (^_^)

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=35149, encodeId=6c3e3514930, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:22:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30836, encodeId=f98830836c4, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30837, encodeId=601f3083e98, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30838, encodeId=03c2308381f, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30839, encodeId=989d308399f, content=(^_^), beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jul 05 16:19:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477958, encodeId=d3eb14e795820, content=<a href='/topic/show?id=dd832018bd' target=_blank style='color:#2F92EE;'>#ADT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2018, encryptionId=dd832018bd, topicName=ADT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87be7387847, createdName=124984e7m85暂无昵称, createdTime=Sun Jul 05 12:31:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30700, encodeId=e9fe30e00f4, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 21:56:00 CST 2015, time=2015-07-04, status=1, ipAttribution=)]
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