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BMJ:偏头痛大幅增加主要心脑血管疾病风险

2018-02-02 zhangfan MedSci原创

研究认为,偏头痛患者心肌梗死、缺血性卒中、出血性卒中、静脉血栓、房颤或房扑风险增加,偏头痛是重要的心脑血管疾病风险因素

近日研究人员通过分析1995-2013年间丹麦所有医院和医院门诊数据,考察了偏头痛患者的心肌梗死、中风、外周动脉疾病、静脉血栓栓塞、房颤和房扑、心力衰竭等心脑血管疾病风险。

51032名偏头痛患者与510320名年龄、性别和就诊时间相匹配的一般人群参与研究。通过COX回归分析偏头痛患者的心血管危险。

随访期间,偏头痛患者的大多数疾病绝对风险高于一般人群。随访19年后,偏头痛人群与一般人群相比,每1000患者年的累积心脑血管疾病事件如下:心肌梗塞25 vs 17;缺血性卒中45 vs 25;出血性卒中11 vs 6;周围动脉疾病13 vs 11;静脉血栓栓塞27 vs 18;房颤或房扑47 vs 34;心力衰竭19 vs 18。偏头痛与心肌梗死(HR,1.49),缺血性卒中(2.26),出血性卒中(1.94),静脉血栓栓塞(1.59),房颤或房扑(1.25)风险增加相关;与周边动脉疾病(1.12)和心衰(1.04)无关。偏头痛发病初期(0-1年内)与中风的相关性高于慢性人群(最多至19年),有偏头痛先兆的人群相关性高于无先兆人群,女性的相关性高于男性。亚组分析显示,偏头痛与主要心脑血管疾病的相关性在调整体重指数和吸烟行为后仍然存在。

研究认为,偏头痛患者心肌梗死、缺血性卒中、出血性卒中、静脉血栓、房颤或房扑风险增加,偏头痛是重要的心脑血管疾病风险因素。

原始出处:


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    2018-12-14 gaoxiaoe
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    2018-02-11 天涯183

    非常好的文章.学习了.很收益

    0

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    2018-02-02 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-02-02 120e71dcm28暂无昵称

    (^_^)

    0

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