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Nurosurgery:儿童闭合性脑损伤可抗血小板或抗凝治疗?

2017-04-11 MedSci MedSci原创

背景:小儿闭合性脑损伤(BCVI)缺乏公认的治疗措施,且对损伤的预后研究较少。目的:比较儿科创伤中心的治疗措施,并描述现有治疗方式的预后。方法:在4家儿科创伤中心收集2003年到2013年间,BCVI患者的临床和影像学资料。结果:评估了645例BCVI儿童的CT血管造影,52例患者中有发生57处血管损伤(82%为颈动脉,18%为椎动脉)。大部分为I级(58%)和II(23%)级损伤。排除严重颅内或

背景:小儿闭合性脑损伤(BCVI)缺乏公认的治疗措施,且对损伤的预后研究较少。

目的:比较儿科创伤中心的治疗措施,并描述现有治疗方式的预后。

方法:在4家儿科创伤中心收集2003年到2013年间,BCVI患者的临床和影像学资料。

结果:评估了645例BCVI儿童的CT血管造影,52例患者中有发生57处血管损伤(82%为颈动脉,18%为椎动脉)。大部分为I级(58%)和II(23%)级损伤。排除严重颅内或腹腔内出血后,对10例患者进行抗血栓治疗。在余下的患者中,14例(33%)进行抗血小板药物治疗,8例(19%)进行抗凝治疗,3例(7%)进行血管内介入治疗,1例(2%)进行开放手术,(38%)未进行治疗。在27例I级损伤患者中,有16例(59%)未接受治疗,选择未治疗方案治疗各中心差异显著(P<0.001)。格拉斯哥昏迷评分(GCS)评分为8,损伤等级增加是损伤进展的预测因素(P =0. 001,P =0. 005)。不良的GCS评分(P =0. 02),增加的损伤等级(P = 0.03),以及随之而来的颅内损伤(P =0. 02)与死亡率风险增加相关。治疗方式与血管损伤或死亡率的进展不相关。

结论:抗血小板或抗凝治疗BCVI治疗是安全的,某种程度上是有益的。一些不可改变的因素,包括GCS评分、血管损伤等级及颅内损伤,仍然是预后较差的重要预测因素。

原文出处:

Dewan, Michael C, et al. Treatment Practices and Outcomes After Blunt Cerebrovascular Injury in Children. December 2016


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  2. [GetPortalCommentsPageByObjectIdResponse(id=2021553, encodeId=2d202021553bc, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Thu Sep 14 05:03:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877686, encodeId=81f618e7686de, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu Mar 22 11:03:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364158, encodeId=4aee136415887, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Apr 13 08:03:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397164, encodeId=f314139e164fa, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Apr 13 08:03:00 CST 2017, time=2017-04-13, status=1, ipAttribution=)]
    2018-03-22 chg121
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    2017-04-13 lsndxfj
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