J Periodontol：牙周疾病的新标志物：唾液集落刺激因子-1和白介素-34

2017-05-09 lishiting MedSci原创

唾液集落刺激因子（CSF）-1、白介素（IL）-34属于巨噬细胞生长因子，也是骨诱裂发生的调控因子。然而，CSF-1和IL-34是否参与了牙周疾病的发生发展过程还未可知。这篇研究的目的是为了检测牙周疾病患者的唾液中是否存在CSF-1和IL-34的表达。

唾液集落刺激因子（CSF）-1、白介素（IL）-34属于巨噬细胞生长因子，也是骨诱裂发生的调控因子。然而，CSF-1和IL-34是否参与了牙周疾病的发生发展过程还未可知。这篇研究的目的是为了检测牙周疾病患者的唾液中是否存在CSF-1和IL-34的表达。

研究首先通过ELISA法在健康志愿者（n=21）的唾液中评估验证实施方案。随后，检测48名患者（29名牙周炎、12名牙龈炎和7名健康）唾液中CSF-1、IL-34和基质金属蛋白酶-8（MMP-8，牙周炎的标志性基因）的表达情况。同时，检测牙周疾病相关的临床指标，包括：探诊出血情况（BOP）、探诊深度（PD）、临床附着丧失（AL）和菌斑指数（PI）。另外一个分组由21名牙龈炎和11名牙周炎患者组成，并且接受过非手术的牙周治疗后，检测其CSF-1、IL-34和MMP-8表达改变以及临床疗效。

结果显示，与健康人群相比，牙周炎患者唾液中存在较高的CSF-1和MMP-8表达，而IL-34表达很低。牙周炎患者中的CSF-1/IL-34率要明显高于健康人群。在牙龈炎和牙周炎中，CSF-1和MMP-8之间存在正相关性，2者与IL-34均呈负相关。另外，牙周疾病患者的临床检查指标与CSF-1、MMP-8和CSF-1/IL-34率呈正相关，而与IL-34呈负相关。治疗后，牙龈炎患者临床疗效显现的同时也伴随着CSF-1和MMP-8表达水平的明显下降。

结论：唾液中存在CSF-1和IL-34的表达，并且2者在牙周疾病中似乎扮演着互补的角色。IL-34的表达比较平稳，而CSF-1在炎症中表达明显。

原始出处：

Martinez GL， Majster M， et al. Salivary Colony Stimulating Factor-1， Interleukin-34， and Matrix Metalloproteinase-8 as Markers of Periodontal Disease. J Periodontol. 2017 May 5：1-15. doi： 10.1902/jop.2017.170081.

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学习了谢谢分享

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2017-05-17 laymankey

感谢分享一下！！

110 0
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2017-05-16 6888

好哦咯JJX5一why

98 0
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2017-05-15 6888

看看姐took明

89 0
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objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jul 14 14:03:00 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450516, encodeId=581f14505167b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484078, encodeId=d4c514840e8f2, content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
2017-05-13 6888

棒棒哒学习了

53 0
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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib18tWbCzYcEibw6Ro7WIJDMuc2wJMj17F3Oj2d6Faia1LawEktGVQSxLd9FMILIQYwDLUK9u9WKDap5VY87R0GjeZ/0, createdBy=0acd1864050, createdName=6888, createdTime=Mon May 15 17:27:55 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197631, encodeId=9f1c19e631bf, content=棒棒哒学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib18tWbCzYcEibw6Ro7WIJDMuc2wJMj17F3Oj2d6Faia1LawEktGVQSxLd9FMILIQYwDLUK9u9WKDap5VY87R0GjeZ/0, createdBy=0acd1864050, createdName=6888, createdTime=Sat May 13 17:56:15 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841009, encodeId=3d2d184100986, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, 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content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
2017-07-14 hukaixun

#标志物#

48 0
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content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
2017-05-11 liuyong2982

#牙周#

58 0
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createdName=收获你的美, createdTime=Tue Jun 20 23:33:54 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208764, encodeId=8ced208e6497, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sat Jun 10 05:29:02 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198953, encodeId=77fd198953ca, content=感谢分享一下！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Wed May 17 00:19:19 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198861, encodeId=ab981988612c, content=好哦咯JJX5一why, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib18tWbCzYcEibw6Ro7WIJDMuc2wJMj17F3Oj2d6Faia1LawEktGVQSxLd9FMILIQYwDLUK9u9WKDap5VY87R0GjeZ/0, createdBy=0acd1864050, createdName=6888, createdTime=Tue May 16 16:59:33 CST 2017, time=2017-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198440, encodeId=2d7619844088, content=看看姐took明, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jul 14 14:03:00 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450516, encodeId=581f14505167b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484078, encodeId=d4c514840e8f2, content=<a href='/topic/show?id=1a296e52078' target=_blank style='color:#2F92EE;'>#牙周疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67520, encryptionId=1a296e52078, topicName=牙周疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0c97946807, createdName=ms7019579240139182, createdTime=Thu May 11 14:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
2017-05-11 ms7019579240139182

#牙周疾病#

81 0

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J Periodontol：牙周疾病的新标志物：唾液集落刺激因子-1和白介素-34

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