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Circulation:亚油酸/花生四烯酸与心血管疾病的发生率和死亡率!

2019-05-26 QQ MedSci原创

亚油酸(LA)是一种主要的膳食欧米伽-6不饱和脂肪酸,代谢物是花生四烯酸(AA),其全球饮食指南尚充满争议。为解决这一确定性,为国际建议提供依据,现研究人员通过多项国际研究评估了亚油酸和花生四烯酸在体内循环/组织水平与突发心血管疾病(CVD)的关系。研究人员对13个国家的30个前瞻性观察性研究进行一个新的分析。在这30个研究中,中位随访时间从2.5年到31.9年,68659位受试者共发生15198

亚油酸(LA)是一种主要的膳食欧米伽-6不饱和脂肪酸,代谢物是花生四烯酸(AA),其全球饮食指南尚充满争议。为解决这一确定性,为国际建议提供依据,现研究人员通过多项国际研究评估了亚油酸和花生四烯酸在体内循环/组织水平与突发血管疾病(CVD)的关系。

研究人员对13个国家的30个前瞻性观察性研究进行一个新的分析。

在这30个研究中,中位随访时间从2.5年到31.9年,68659位受试者共发生15198例血管意外事件。高亚油酸水平与CVD、心血管死亡率和缺血性发作的总体风险降低相关,每四分位数范围的风险比分别是0.93(95% CI 0.88-0.99)、0.78 (0.70–0.85)和0.88 (0.79–0.98);与低冠心病风险无明显关系(0.94,0.88-1.00)。以五分位数评估亚油酸的相关性结果相似。花生四烯酸水平与心血管事件高风险无关;在极端五分位数的比较中,花生四烯酸较高水平与较低的总CVD风险相关(0.92;0.86-0.99)。人群之间无异质性。

在本全球汇总分析中,体内循环/组织较高水平的亚油酸与较低的大心血管事件风险相关,花生四烯酸可能有关。本结果表明亚油酸在CVD预防中具有良好作用。

原始出处:

Matti Marklund,et al. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality. Circulation. 21 May 2019.https://doi.org/10.1161/CIRCULATIONAHA.118.038908. 2019;139:2422–2436

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