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JACC:肥胖可增加主动脉瓣狭窄的发病风险

2020-01-16 不详 MedSci原创

主动脉瓣狭窄的常规危险因素鲜有认知,本研究提出假设,以体重指数衡量的遗传性肥胖与主动脉瓣狭窄和置换的风险密切相关。本研究纳入分析了108211名对象,参与者测量了体重指数、腰臀比和腰围,以及与肥胖相关的5种基因变异的信息。经过平均8.7年时间的随访,有1215名患者出现主动脉瓣狭窄,其中467名患者接受了置换手术。遗传引起的体重指数增高与主动脉瓣风险增高相关,体重指数每增加1kg/m2,主动脉瓣狭

主动脉瓣狭窄的常规危险因素鲜有认知,本研究提出假设,以体重指数衡量的遗传性肥胖与主动脉瓣狭窄和置换的风险密切相关。

本研究纳入分析了108211名对象,参与者测量了体重指数、腰臀比和腰围,以及与肥胖相关的5种基因变异的信息。经过平均8.7年时间的随访,有1215名患者出现主动脉瓣狭窄,其中467名患者接受了置换手术。遗传引起的体重指数增高与主动脉瓣风险增高相关,体重指数每增加1kg/m2,主动脉瓣狭窄发表和置换手术的风险比分别为1.52 (95% CI: 1.23 - 1.87) 和1.49 (95% CI: 1.07 - 2.08)。

研究结果显示,遗传性肥胖与主动脉瓣狭窄发病和置换手术的风险增高呈相关性。

原始出处:

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