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J Periodontal Implant Sci:使用氯己定和盐酸米诺环素简化非手术治疗种植体周围炎

2018-12-15 MedSci MedSci原创

本研究旨在探究使用氯己定溶液和盐酸米诺环素(HCl)对种植体周骨缺损区进行骨内给药的治疗效果。研究共纳入了诊断为种植体周围炎的20名患者,包括45个牙种植体。在基线和研究终点时,记录每个植入物周围6个部位的探诊深度(PPD),临床附着水平(CAL)和探测出血(BOP)。在每个植入物的近中或远侧近端方面的X线骨缺损形态被分类为1)窄或宽和2)浅或深。对于根据缺损形态的骨变化的比较分析,在基线和终点处

本研究旨在探究使用氯己定溶液和盐酸米诺环素(HCl)对种植体周骨缺损区进行骨内给药的治疗效果。

研究共纳入了诊断为种植体周围炎的20名患者,包括45个牙种植体。在基线和研究终点时,记录每个植入物周围6个部位的探诊深度(PPD),临床附着水平(CAL)和探测出血(BOP)。在每个植入物的近中或远侧近端方面的X线骨缺损形态被分类为1)窄或宽和2)浅或深。对于根据缺损形态的骨变化的比较分析,在基线和终点处测量每颗植体的近中和远中方面从植体肩部到最冠状骨-植体接触点(DIB)的距离。患者计划每2-4周访问一次诊所,进行血清灌洗氯己定和输送盐酸米诺环素。

结果显示,治疗后PPD,CAL和BOP均有明显的统计学意义的降低。在终点处,无论骨内缺损的骨形态如何,所有骨缺损中的骨水平均增加。深部骨缺损的平均DIB变化明显大于浅层骨缺损。虽然狭窄缺损的平均骨增益大于宽缺损,但差异无统计学意义。

综上所述,我们建议,当牙种植体周围的骨内缺损通过简单的非手术方法进行管理时,可以预期临床和放射学参数的显着和可持续的改进,包括联合肌内注射氯己定和局部递送盐酸米诺环素。

原始出处:

SunJin Heo, Hyun-Joo Kim, et al., Simplified nonsurgical treatment of peri-implantitis using chlorhexidine and minocycline hydrochloride. J Periodontal Implant Sci. 2018 Oct; 48(5): 326–333.

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    2019-09-15 xuyong536
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    2019-06-17 xuyu
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    2019-11-01 huangdf
  4. 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style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Mon Dec 17 10:36:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
    2019-08-26 feather89
  5. 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style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Mon Dec 17 10:36:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
  6. 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  7. 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style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Mon Dec 17 10:36:00 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1773250, encodeId=23ba1e73250d6, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Sun Sep 15 07:36:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789229, encodeId=5ca01e89229d9, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Mon Jun 17 20:36:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702027, encodeId=bcdd1e020270a, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Fri Nov 01 22:36:00 CST 2019, time=2019-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727775, encodeId=7f971e277758a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Aug 26 08:36:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290661, encodeId=16d812906617b, content=<a href='/topic/show?id=e86454454ea' target=_blank style='color:#2F92EE;'>#手术治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54454, encryptionId=e86454454ea, topicName=手术治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Dec 17 10:36:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343860, encodeId=7bb0134386010, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Dec 17 10:36:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344617, encodeId=7f29134461efe, content=<a href='/topic/show?id=37286409571' target=_blank style='color:#2F92EE;'>#氯己定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64095, encryptionId=37286409571, topicName=氯己定)], attachment=null, authenticateStatus=null, 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  9. 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