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Europace:轻度低血钾对动态心律失常及其预后的影响

2015-08-25 MedSci MedSci原创

目的:严重低血钾恶化心律失常及其预后,但是轻度低血钾的对心率失常的影响尚不清楚。我们主要是想确定轻度低血钾与动态心率失常及其预后的关系。方法和结果:从“哥本哈根的动态研究”中选取没有明显心血管(CV)疾病或卒中病史的研究对象671名。对所有研究对象进行实验室检查和48h动态心电图检查。随访时间的中位数为6.3年。血钾与频发室性早搏(PVC)的发生呈负相关,尤其是与利尿剂联合应用时(r = -0.2

目的:严重低血钾会恶化心律失常及其预后,但是轻度低血钾的对心率失常的影响尚不清楚。我们主要是想确定轻度低血钾与动态心率失常及其预后的关系。

方法和结果:从“哥本哈根的动态研究”中选取没有明显心血管(CV)疾病或卒中病史的研究对象671名。对所有研究对象进行实验室检查和48h动态心电图检查。随访时间的中位数为6.3年。血钾与频发室性早搏(PVC)的发生呈负相关,尤其是与利尿剂联合应用时(r = -0.22)。低血钾与室上性心律失常发生无关。研究对象血钾浓度在2.7-3.6 mmol/L之间,平均血钾浓度为3.42mmol/L,将其定义为低血钾。低血钾患者心血管死亡率较高(HR和CI分别为 2.62 (1.11-6.18))。低血钾并发PVC恶化患者预后;发生率:每年两者均发生的概率为8.3%。每年发生一种情况的为1%和1.5%。每年两者均正常的发生率为0.3%。在单变量分析中,低血钾并发频发室上性心律失常得到与频发室性早搏相同的结果,但在多变量校正后,没有得到相同的结果。

结论:在没有明显心脏病的中老年研究对象中,轻度低血钾与室性心律失常的发生相关,与室上性心律失常失常的发生无关。低血钾与室性心率失常共同作用,增加不良事件的发生。

原文出处:


Mattsson N, Sadjadieh G, Kumarathurai P,et al.Ambulatory cardiac arrhythmias in relation to mild hypokalaemia and prognosis in community dwelling middle-aged and elderly subjects. Europace. 2015 Aug 19. pii: euv204. [Epub ahead of print]


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    2016-06-04 shanyongle
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    2015-08-30 Keren1970

    低钾与室性心律失常相关

    0

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