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Int Forum Allergy Rhinol:慢性鼻窦炎严重程度与经济状态和空气污染物暴露的关系

2021-10-02 AlexYang MedSci原创

评估SES和吸入性污染物暴露与CRS疾病严重程度之间的关系。

慢性鼻炎(CRS)是一种多因素引起的炎症性疾病,受人体与环境的相互作用以及社会经济因素的影响。然而,关于环境暴露和社会经济地位(SES)对CRS疾病表现和严重程度的影响,目前还没有什么数据。

空气污染物直接与气道粘膜相互作用,但污染物如何影响上气道炎症却知之甚少。既往研究表明,在交通污染较重的地区,慢性鼻炎(CRS)、鼻炎和哮喘的发病率增加,而这些地区往往社会经济状况(SES)较差。研究人员根据邮政编码,使用区域剥夺指数(ADI)评估了社区级别的社会经济状况。研究的目的是评估SES和吸入性污染物暴露与CRS疾病严重程度之间的关系

研究包括了患有或不患有鼻息肉的CRS患者(分别为CRSwNP和CRSsNP)(总人数=234;CRSwNP患者=138;CRSsNP患者=96)。研究人员测量了污染物浓度,包括颗粒物2.5(PM2.5)、黑碳(BC)和二氧化氮(NO2),并用于估计病人的暴露程度。疾病严重程度评判指标包括改良的Lund-Mackay评分(LMS),对全身性类固醇的需求,以及功能性内窥镜鼻窦手术(FESS)的使用。通过线性、逻辑和泊松多变量回归分析确定了相关关系。

结果发现,CRSsNP和CRSwNP患者的地域分布相似。ADI是暴露于空气污染物(PM2.5、BC和NO2)的预测因素,ADI每增加一个十分位数,PM2.5、BC和NO2分别增加1.39%、2.39%和2.49%(P<0.0001),表明贫困社区与较高的PM2.5、BC和NO2暴露水平有直接关系,即ADI每增加一个十分位数,污染物水平就增加。此外,ADI也是类固醇治疗的一个预测因素

ADI与空气污染物水平的关系

综上所述,较低的SES预示着较高的空气污染暴露,以及更高的CRS疾病严重程度

原始出处:

Nathalia Velasquez , Lauren Gardiner , Tracy Z Cheng et al. Relationship between socioeconomic status, exposure to airborne pollutants, and chronic rhinosinusitis disease severity. Int Forum Allergy Rhinol. Sep 2021

 

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    2021-10-04 膀胱癌
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