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Eur Radiol: 爱护膝关节,一定要注意这一个小动作!

2021-03-05 shaosai MedSci原创

髌股(PF)骨关节炎(OA)在全球成年人中的患病率约为25%,是导致膝关节疼痛和残疾的主要原因之一。

    髌股(PF)骨关节炎(OA)在全球成年人中的患病率约为25%,是导致膝关节疼痛和残疾的主要原因之一。尽管PF OA具有很高的临床重要性和患病率,但尚未有研究全面评估PF OA的主要危险因素和体育活动对该疾病发生率及进展的影响。

    PF OA的进展主要是使用膝关节x线平片,然而这种方法对早期及细微的软骨改变并不敏感。磁共振成像(MRI)是显示软骨改变最有优势的影像学方法。一些报告显示包括高位髌骨(PA)在内的PF形态异常是PF OA进展的重要预测因子。PA被定义为相对于滑车沟的高位的髌骨,在膝关节伸展和屈曲运动中可能导致PF关节不稳定。PA减少了膝关节运动时髌骨与滑车之间的接触面积,导致关节面接触压力的增加,从而导致PF骨性关节炎。Insall-Salvati比率(ISR)是一种通过矢状面MRI、CT或膝关节侧位片确定PA的有效测量方法。


    近日,发表在European Radiology杂志的一项研究有/无髌骨高位(PA)受试者中,跪姿是否与MRI测量的髌股(PF)关节软骨损伤恶化有关,进一步了解了PF OA的发病机制,为临床预防及减缓OA的发展提供了新的参考依据。

    提取来自FNIH研究(骨关节炎计划(OAI)内嵌套研究)的600名受试者的基线时和24个月的3-T MR图像以及PF关节的半定量MRI骨关节炎膝关节评分(MOAKS)。在基线时,询问受试者每周有多少天持续30分钟以上的跪姿动作。由骨肌专业放射科医生在基线MRI上测量Insall-Salvati比率(ISR)(髌骨肌腱/髌骨高度),ISR≥1.3视为PA。校正了混杂变量的回归分析被用来评价跪姿动作对24个月MOAKS软骨恶化的影响。采用校正回归分析评价PA的潜在调节作用。

    本研究共纳入600名受试者(58.8%女性,年龄,BMI = 30.7±4.8 kg/m2);每周有1天、2-5天和≥6天跪姿活动的受试者所占分别为13.7%、6.2%和5.5%。更高频率的跪姿活动与MOAKS软骨评分恶化的风险增加有相关性(校正OR (95% CI): 2.33(1.08-5.06))。分层分析显示,只有跪姿活动≥6天/周与MOAKS软骨评分恶化相关(2.74(1.03-7.27))。当我们在回归模型中纳入PA时,跪姿活动与PF软骨损伤相关性的OR (95% CI)下降到1.26(0.78-2.04),表明PA可能作为调节变量发挥潜在作用。

图 跪姿活动频繁(≥6天/周)患者的Insall-Salvati比率和MRI骨关节炎膝关节评分(MOAKS)。59岁女性,髌骨高位,跪姿活动频繁。Insall-Salvati比值为基线时MRI上髌韧带长度除以髌骨长度,本例≥1.3。基线时MRI矢状位(a)和轴位(b) 显示轻度至中度PF软骨缺损,半定量MRI骨关节炎膝关节评分(MOAKS)的表面和全层评分为2(10-75%的软骨表面和厚度受累)。随访同一患者24个月时MRI的矢状位(c)和轴位(d) 显示PF软骨损伤的表面和全层评分均恶化。软骨下新的骨髓病变也可以在随访图像中检测到。56岁女性,跪姿活动频繁,Insall-Salvati比< 1.3。基线时MRI矢状(e)和轴向(f)的TSE序列, 同一病例24个月随访时MRI的矢状位(H)和轴位 (G)图像显示没有MOAKS分数上的PF软骨损伤的恶化。

    长时间的跪姿活动(≥6天/周)与PF软骨损伤恶化相关,在髌骨高位的受试者中尤为明显。这提示高危人群需减少相应活动以避免骨关节炎的发生和发展,为临床对相应患者的治疗及管理提供了有意义的指导性意见。


原地出处:

Arya Haj-Mirzaian,Bahram Mohajer,Ali Guermazi,et al. Kneeling as a risk factor of patellofemoral joint cartilage damage worsening: an exploratory analysis on the Osteoarthritis Initiative.DOI:10.1007/s00330-020-07337-z

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1748541, encodeId=7b431e485414d, content=<a href='/topic/show?id=b1f856031df' target=_blank style='color:#2F92EE;'>#护膝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56031, encryptionId=b1f856031df, topicName=护膝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb2136165521, createdName=whmdzju, createdTime=Sun Nov 07 05:37:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945822, encodeId=6d71945822ae, content=所以日本人发病率高, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Fri Mar 05 20:12:03 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945706, encodeId=ba9d945e0698, content=骨关节炎是膝关节疼痛的主要原因, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Fri Mar 05 12:55:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945676, encodeId=1a749456e69b, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri Mar 05 11:17:25 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945672, encodeId=2b419456e272, content=有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=716c5465786, createdName=ms9000001767033765, createdTime=Fri Mar 05 11:08:27 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
    2021-11-07 whmdzju
  2. [GetPortalCommentsPageByObjectIdResponse(id=1748541, encodeId=7b431e485414d, content=<a href='/topic/show?id=b1f856031df' target=_blank style='color:#2F92EE;'>#护膝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56031, encryptionId=b1f856031df, topicName=护膝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb2136165521, createdName=whmdzju, createdTime=Sun Nov 07 05:37:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945822, encodeId=6d71945822ae, content=所以日本人发病率高, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Fri Mar 05 20:12:03 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945706, encodeId=ba9d945e0698, content=骨关节炎是膝关节疼痛的主要原因, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Fri Mar 05 12:55:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945676, encodeId=1a749456e69b, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri Mar 05 11:17:25 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945672, encodeId=2b419456e272, content=有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=716c5465786, createdName=ms9000001767033765, createdTime=Fri Mar 05 11:08:27 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
    2021-03-05 liyu7822

    所以日本人发病率高

    0

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    2021-03-05 科研科研科研

    骨关节炎是膝关节疼痛的主要原因

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1748541, encodeId=7b431e485414d, content=<a href='/topic/show?id=b1f856031df' target=_blank style='color:#2F92EE;'>#护膝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56031, encryptionId=b1f856031df, topicName=护膝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb2136165521, createdName=whmdzju, createdTime=Sun Nov 07 05:37:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945822, encodeId=6d71945822ae, content=所以日本人发病率高, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Fri Mar 05 20:12:03 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945706, encodeId=ba9d945e0698, content=骨关节炎是膝关节疼痛的主要原因, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Fri Mar 05 12:55:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945676, encodeId=1a749456e69b, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri Mar 05 11:17:25 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945672, encodeId=2b419456e272, content=有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=716c5465786, createdName=ms9000001767033765, createdTime=Fri Mar 05 11:08:27 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
    2021-03-05 威天

    很有用

    0

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    2021-03-05 ms9000001767033765

    有帮助

    0

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