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Arch Phys Med Rehabil:运动训练可有效改善老年患者的痴呆表现

2021-04-18 MedSci原创 MedSci原创

痴呆症是一种精神障碍,可影响患者的认知功能,降低生活质量,为家庭和社会带来巨大的经济负担。近日,一项单盲随机对照试验探究了力量或有氧训练是否可改善老年痴呆患者的日常生活能力,并确定运动对患者认知、抑郁

痴呆症是一种精神障碍,可影响患者的认知功能,降低生活质量,为家庭和社会带来巨大的经济负担。近日,一项单盲随机对照试验探究了力量或有氧训练是否可改善老年痴呆患者的日常生活能力,并确定运动对患者认知、抑郁和生化标志物的影响,研究结果已发表于Arch Phys Med Rehabil。

 

 

研究在一个退伍军人的疗养院进行,纳入了80名老年患者,迷你精神状态检查的分数在15到26分之间。排除11名由于心肺或骨科疾病而无法进行运动训练回答问卷的参与者。在运动训练期间,有8名参与者自愿退出研究。

 

将参与者随机分配进行力量或有氧训练,共4周。主要结果测量是Barthel指数。次要结果测量包括迷你精神状态检查、蒙特利尔认知评估、老年抑郁量表、血浆单核细胞趋化蛋白-1水平、胰岛素样生长因子-1水平和血清脑源性神经营养因子水平。

 

结果显示,完成项目训练后,力量训练组患者的巴特尔指数、迷你精神状态检查、蒙特利尔认知评估和血浆单核细胞化学活性蛋白-1水平均有显著改善。对于接受过有氧训练的患者,其血清脑源性神经营养因子也有明显改善。但是,这些改善没有显著的组间差异。

综上所述,该研究结果表明,无论是力量训练还是有氧训练,为期4周的强化运动计划都能为老年痴呆症患者带来显著的益处,而通过有氧训练,还可改善患者血清中的脑源性神经营养因子的水平。

 

原始出处:

 

I-Ting Liu, et al., Therapeutic Effects of Exercise Training on Elderly Patients With Dementia: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 May;101(5):762-769. doi: 10.1016/j.apmr.2020.01.012. 

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    2021-07-13 丫丫笑笑

    学习了

    0

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    2021-04-22 691273246

    学习一下

    0

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    2021-04-22 十八线开外美少女

    有氧运动改善老年痴呆

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1954928, encodeId=274b195492894, content=<a href='/topic/show?id=d5079422460' target=_blank style='color:#2F92EE;'>#运动训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94224, encryptionId=d5079422460, topicName=运动训练)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Oct 22 04:03:26 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999136, encodeId=c98d99913683, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/e9400b10040c42c19853620456dabe53/b137ed05fedf4c1b9bf132fd567c1670.jpg, createdBy=0eed5532793, createdName=丫丫笑笑, createdTime=Tue Jul 13 17:05:34 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959583, encodeId=5cd0959583a5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b032823267, createdName=691273246, createdTime=Thu Apr 22 21:20:44 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959386, encodeId=2c7e95938650, content=有氧运动改善老年痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220709/a510c1d082a042b5b7d85344c7f8539a/000346081d9f44ca9473cfda715d2eea.jpg, createdBy=5eec5483989, createdName=十八线开外美少女, createdTime=Thu Apr 22 14:15:40 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521989, encodeId=aff8152198964, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611009, encodeId=20fb16110095b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958368, encodeId=2c0695836863, content=无论是力量训练还是有氧训练,为期4周的强化运动计划都能为老年痴呆症患者带来显著的益处,而通过有氧训练,还可改善患者血清中的脑源性神经营养因子的水平。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b515466016, createdName=ms5000002050027133, createdTime=Mon Apr 19 14:03:32 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958324, encodeId=6dfd95832460, content=神奇神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:24:06 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048766, encodeId=42a71048e66ea, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Mon Apr 19 00:03:26 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958093, encodeId=fde4958093e8, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0945446315, createdName=ms1000000998771471, createdTime=Sun Apr 18 21:32:26 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-20 qjddjq
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    2021-04-19 ms5000002050027133

    无论是力量训练还是有氧训练,为期4周的强化运动计划都能为老年痴呆症患者带来显著的益处,而通过有氧训练,还可改善患者血清中的脑源性神经营养因子的水平。

    0

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    2021-04-19 ZJYYY7

    神奇神奇

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1954928, encodeId=274b195492894, content=<a href='/topic/show?id=d5079422460' target=_blank style='color:#2F92EE;'>#运动训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94224, encryptionId=d5079422460, topicName=运动训练)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Oct 22 04:03:26 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999136, encodeId=c98d99913683, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/e9400b10040c42c19853620456dabe53/b137ed05fedf4c1b9bf132fd567c1670.jpg, createdBy=0eed5532793, createdName=丫丫笑笑, createdTime=Tue Jul 13 17:05:34 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959583, encodeId=5cd0959583a5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b032823267, createdName=691273246, createdTime=Thu Apr 22 21:20:44 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959386, encodeId=2c7e95938650, content=有氧运动改善老年痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220709/a510c1d082a042b5b7d85344c7f8539a/000346081d9f44ca9473cfda715d2eea.jpg, createdBy=5eec5483989, createdName=十八线开外美少女, createdTime=Thu Apr 22 14:15:40 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521989, encodeId=aff8152198964, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611009, encodeId=20fb16110095b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958368, encodeId=2c0695836863, content=无论是力量训练还是有氧训练,为期4周的强化运动计划都能为老年痴呆症患者带来显著的益处,而通过有氧训练,还可改善患者血清中的脑源性神经营养因子的水平。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b515466016, createdName=ms5000002050027133, createdTime=Mon Apr 19 14:03:32 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958324, encodeId=6dfd95832460, content=神奇神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:24:06 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048766, encodeId=42a71048e66ea, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Mon Apr 19 00:03:26 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958093, encodeId=fde4958093e8, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0945446315, createdName=ms1000000998771471, createdTime=Sun Apr 18 21:32:26 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-19 junJUN

    老年人痴呆何药可用??

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1954928, encodeId=274b195492894, content=<a href='/topic/show?id=d5079422460' target=_blank style='color:#2F92EE;'>#运动训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94224, encryptionId=d5079422460, topicName=运动训练)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Oct 22 04:03:26 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999136, encodeId=c98d99913683, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/e9400b10040c42c19853620456dabe53/b137ed05fedf4c1b9bf132fd567c1670.jpg, createdBy=0eed5532793, createdName=丫丫笑笑, createdTime=Tue Jul 13 17:05:34 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959583, encodeId=5cd0959583a5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b032823267, createdName=691273246, createdTime=Thu Apr 22 21:20:44 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959386, encodeId=2c7e95938650, content=有氧运动改善老年痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220709/a510c1d082a042b5b7d85344c7f8539a/000346081d9f44ca9473cfda715d2eea.jpg, createdBy=5eec5483989, createdName=十八线开外美少女, createdTime=Thu Apr 22 14:15:40 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521989, encodeId=aff8152198964, content=<a href='/topic/show?id=f83866137f' target=_blank style='color:#2F92EE;'>#EHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6613, encryptionId=f83866137f, topicName=EHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937d11405368, createdName=qjddjq, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611009, encodeId=20fb16110095b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Apr 20 12:03:26 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958368, encodeId=2c0695836863, content=无论是力量训练还是有氧训练,为期4周的强化运动计划都能为老年痴呆症患者带来显著的益处,而通过有氧训练,还可改善患者血清中的脑源性神经营养因子的水平。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b515466016, createdName=ms5000002050027133, createdTime=Mon Apr 19 14:03:32 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958324, encodeId=6dfd95832460, content=神奇神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:24:06 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048766, encodeId=42a71048e66ea, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Mon Apr 19 00:03:26 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958093, encodeId=fde4958093e8, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0945446315, createdName=ms1000000998771471, createdTime=Sun Apr 18 21:32:26 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-18 ms1000000998771471

    学习一下

    0

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