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Acta Derm Venereol:重复性日光光动力疗法 vs. 冷冻手术预防面部皮肤光化性角化病的疗效

2021-09-01 MedSci原创 MedSci原创

光化性角化病是紫外线损伤皮肤的一种慢性病,有发展为浸润性皮肤癌的风险。近日,发表于Acta Derm Venereol的一项随机试验调查了场定向重复日光光动力疗法对日光性角化病的预防潜力。

光化性角化病是紫外线损伤皮肤的一种慢性病,有发展为浸润性皮肤癌的风险。近日,发表于Acta Derm Venereol的一项随机试验调查了场定向重复日光光动力疗法对日光性角化病的预防潜力。

该研究纳入了58名面部皮肤光损伤≥5个光化性角化病的患者,他们在2年内接受了5次全脸日光光动力疗法或病灶定向冷冻疗法。主要结果是在第2次访问和第6次访问(第6次访问为随访)之间新出现的光化性角化病的平均累积数量。

 

结果显示,与冷冻手术相比,日间光动力疗法的主要结果较低:7.7 vs. 10.2,但差异没有显著性(-2.5,95%置信区间-6.2至1.2;P=0.18)。光老化的几种迹象(细纹、色素沉着、粗糙、红斑、皮脂腺增生)在日光光动力疗法后明显减少,但在冷冻手术后没有减少。与冷冻手术相比,日间光动力疗法期间的疼痛和副作用明显减少。

综上所述,这项研究发现,重复性的日光光动力疗法具有光子嫩肤作用。然而,这种疗法对光化性角化病的预防并没有统计学上的明显改善。

 

原始出处:

 

Sigrid Karrer, et al., Repetitive Daylight Photodynamic Therapy versus Cryosurgery for Prevention of Actinic Keratoses in Photodamaged Facial Skin: A Prospective, Randomized Controlled Multicentre Two-armed Study. Acta Derm Venereol. 2021 Jan 4;101(1):adv00355. doi: 10.2340/00015555-3717.

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    2022-07-25 珙桐
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    2022-04-23 windight
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    2021-09-02 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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