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Sci Rep:超敏超声微血管成像中的肿瘤血管生成无创性无对比3D评估

2019-04-03 AlexYang MedSci原创

当超快平面波采集与超声微脉管成像(UMI)结合起来使用时,与传统的多普勒成像相比,能够产生更高的血管信号敏感性。最近,有研究人员提出了一个高空间分辨率和超敏感UMI,该系统基于常规逐行高频超声成像仪和奇异值分解(SVD)杂波过滤的可视化和肿瘤微血管系统和灌注的定量来进行的。研究人员将该技术应用于一个肾细胞肿瘤的鸡胚胎肿瘤模型,该模型利用临床相关剂量的FDA批准的抗血管生成的药物处理。研究阐释了利用

当超快平面波采集与超声微脉管成像(UMI)结合起来使用时,与传统的多普勒成像相比,能够产生更高的血管信号敏感性。最近,有研究人员提出了一个高空间分辨率和超敏感UMI,该系统基于常规逐行高频超声成像仪和奇异值分解(SVD)杂波过滤的可视化和肿瘤微血管系统和灌注的定量来进行的。

研究人员将该技术应用于一个肾细胞肿瘤的鸡胚胎肿瘤模型,该模型利用临床相关剂量的FDA批准的抗血管生成的药物处理。研究阐释了利用UMI进行3D评估来获得微管系统高敏感检测的可行性,并且使用的是临床前和商业化可利用的高频超声设备进行常规逐行超声成像,且没有软件或者硬件的修改。来源于UMI成像的定量参数(血管化指数和分级运动血容量)与传统的多普勒超声相比能够显著的改善对抗血管生成治疗响应的评估,并利用组化分析和免疫组化分析作为参考标准。

最后,研究人员指出,他们的概念验证阐释了高频UMI是一种肿瘤鉴定低花费、无造影剂、易使用、易获得和定量成像的工具,也许在临床前评估和纵向抗癌治疗检测中很有应用价值。

原始出处:

Chengwu Huang, Matthew R. Lowerison, Fabrice Lucien et al. Noninvasive Contrast-Free 3D Evaluation of Tumor Angiogenesis with Ultrasensitive Ultrasound Microvessel Imaging. Sci Rep. 20 Mar 2019.

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    2019-04-05 mgqwxj

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肾肿瘤的分期对预后十分重要,此外淋巴结转移与不良预后有关。通常使用免疫组织化学和显微镜观察对淋巴结是否转移进行评估,这个过程十分耗时,并且可能漏掉微小转移。 我们对另一种检测前哨淋巴结(SNs)转移细胞的方法进行了评估。该方法基于流式细胞仪。 流式细胞仪是对细胞进行自动分析和分选的装置。它可以快速测量、存贮、显示悬浮在液体中的分散细胞的一系列重要的生物物理、生物化学方面的特征参量,并可

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